Dynamic covalent hydrogel of natural product baicalin with antibacterial activities
Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show...
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| Veröffentlicht in: | RSC advances 2022-03, Vol.12 (14), p.8737-8742 |
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| container_title | RSC advances |
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| creator | Wang, Zhen-Zhen Jia, Yuan Wang, Guoqiang He, Hongjuan Cao, Lihua Shi, Yanmei Miao, Mingsan Li, Xiu-Min |
| description | Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show low baicalin loading capacity. Herein, we discovered a dynamic covalent hydrogel only consisting of baicalin and inorganic borate, in which baicalin is considered as the carrier and drug without other ingredients. The dynamic boronate bonds endow the hydrogel with excellent degradability and multi-stimuli-responsiveness. Moreover, the hydrogel displayed remarkable thixotropy, moldability, and self-healing properties. And the biocompatible baicalin hydrogel exhibited significant antibacterial activities, and can be considered as a potential drug delivery system for biomedical applications.
We discovered a dynamic covalent hydrogel with 3D pore structure, in which baicalin were linked by boronate esters. The baicalin hydrogel displayed remarkable thixotropy, moldability, self-healing, and multi-stimuli-responsive properties. |
| doi_str_mv | 10.1039/d1ra07553e |
| format | Article |
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We discovered a dynamic covalent hydrogel with 3D pore structure, in which baicalin were linked by boronate esters. The baicalin hydrogel displayed remarkable thixotropy, moldability, self-healing, and multi-stimuli-responsive properties.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d1ra07553e</identifier><identifier>PMID: 35424809</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biocompatibility ; Biomedical materials ; Chemistry ; Drug delivery systems ; Hydrogels ; Ingredients ; Moldability ; Natural products ; Solubility ; Thixotropy</subject><ispartof>RSC advances, 2022-03, Vol.12 (14), p.8737-8742</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2022</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-e741ab5e13c71c995d0eb250a37447c8ff5cc56e21a98efe0354d62d0324a4863</citedby><cites>FETCH-LOGICAL-c469t-e741ab5e13c71c995d0eb250a37447c8ff5cc56e21a98efe0354d62d0324a4863</cites><orcidid>0000-0001-6961-4367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984956/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984956/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35424809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhen-Zhen</creatorcontrib><creatorcontrib>Jia, Yuan</creatorcontrib><creatorcontrib>Wang, Guoqiang</creatorcontrib><creatorcontrib>He, Hongjuan</creatorcontrib><creatorcontrib>Cao, Lihua</creatorcontrib><creatorcontrib>Shi, Yanmei</creatorcontrib><creatorcontrib>Miao, Mingsan</creatorcontrib><creatorcontrib>Li, Xiu-Min</creatorcontrib><title>Dynamic covalent hydrogel of natural product baicalin with antibacterial activities</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show low baicalin loading capacity. Herein, we discovered a dynamic covalent hydrogel only consisting of baicalin and inorganic borate, in which baicalin is considered as the carrier and drug without other ingredients. The dynamic boronate bonds endow the hydrogel with excellent degradability and multi-stimuli-responsiveness. Moreover, the hydrogel displayed remarkable thixotropy, moldability, and self-healing properties. And the biocompatible baicalin hydrogel exhibited significant antibacterial activities, and can be considered as a potential drug delivery system for biomedical applications.
We discovered a dynamic covalent hydrogel with 3D pore structure, in which baicalin were linked by boronate esters. The baicalin hydrogel displayed remarkable thixotropy, moldability, self-healing, and multi-stimuli-responsive properties.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Drug delivery systems</subject><subject>Hydrogels</subject><subject>Ingredients</subject><subject>Moldability</subject><subject>Natural products</subject><subject>Solubility</subject><subject>Thixotropy</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkV1LHDEUhkOxVLHe9L5lwBsRtuZ7JjcF8RsEoR_X4UzmjBuZnWyTzMr-e6Nrt7a5yYHz8PIkLyGfGP3KqDAnHYtAa6UEviN7nEo941SbnTfzLjlI6YGWoxXjmn0gu0JJLhtq9siP8_UIC-8qF1Yw4Jir-bqL4R6HKvTVCHmKMFTLGLrJ5aoF72DwY_Xo87yCMfsWXMboC1MGv_LZY_pI3vcwJDx4vffJr8uLn2fXs9u7q5uz09uZk9rkGdaSQauQCVczZ4zqKLZcURC1lLVr-l45pzRyBqbBHmmx7jTvqOASZKPFPvm2yV1O7QI7V-yLrF1Gv4C4tgG8_Xcz-rm9DyvbmEYa9Rxw9BoQw-8JU7YLnxwOA4wYpmR5-TDdaKXqgh7-hz6EKY7leYWSTAihX4yON5SLIaWI_VaGUftclz1n309f6roo8Je3-lv0TzkF-LwBYnLb7d--xRM1n5rJ</recordid><startdate>20220315</startdate><enddate>20220315</enddate><creator>Wang, Zhen-Zhen</creator><creator>Jia, Yuan</creator><creator>Wang, Guoqiang</creator><creator>He, Hongjuan</creator><creator>Cao, Lihua</creator><creator>Shi, Yanmei</creator><creator>Miao, Mingsan</creator><creator>Li, Xiu-Min</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6961-4367</orcidid></search><sort><creationdate>20220315</creationdate><title>Dynamic covalent hydrogel of natural product baicalin with antibacterial activities</title><author>Wang, Zhen-Zhen ; Jia, Yuan ; Wang, Guoqiang ; He, Hongjuan ; Cao, Lihua ; Shi, Yanmei ; Miao, Mingsan ; Li, Xiu-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-e741ab5e13c71c995d0eb250a37447c8ff5cc56e21a98efe0354d62d0324a4863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Drug delivery systems</topic><topic>Hydrogels</topic><topic>Ingredients</topic><topic>Moldability</topic><topic>Natural products</topic><topic>Solubility</topic><topic>Thixotropy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhen-Zhen</creatorcontrib><creatorcontrib>Jia, Yuan</creatorcontrib><creatorcontrib>Wang, Guoqiang</creatorcontrib><creatorcontrib>He, Hongjuan</creatorcontrib><creatorcontrib>Cao, Lihua</creatorcontrib><creatorcontrib>Shi, Yanmei</creatorcontrib><creatorcontrib>Miao, Mingsan</creatorcontrib><creatorcontrib>Li, Xiu-Min</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhen-Zhen</au><au>Jia, Yuan</au><au>Wang, Guoqiang</au><au>He, Hongjuan</au><au>Cao, Lihua</au><au>Shi, Yanmei</au><au>Miao, Mingsan</au><au>Li, Xiu-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic covalent hydrogel of natural product baicalin with antibacterial activities</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-03-15</date><risdate>2022</risdate><volume>12</volume><issue>14</issue><spage>8737</spage><epage>8742</epage><pages>8737-8742</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show low baicalin loading capacity. Herein, we discovered a dynamic covalent hydrogel only consisting of baicalin and inorganic borate, in which baicalin is considered as the carrier and drug without other ingredients. The dynamic boronate bonds endow the hydrogel with excellent degradability and multi-stimuli-responsiveness. Moreover, the hydrogel displayed remarkable thixotropy, moldability, and self-healing properties. And the biocompatible baicalin hydrogel exhibited significant antibacterial activities, and can be considered as a potential drug delivery system for biomedical applications.
We discovered a dynamic covalent hydrogel with 3D pore structure, in which baicalin were linked by boronate esters. The baicalin hydrogel displayed remarkable thixotropy, moldability, self-healing, and multi-stimuli-responsive properties.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35424809</pmid><doi>10.1039/d1ra07553e</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6961-4367</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Biocompatibility Biomedical materials Chemistry Drug delivery systems Hydrogels Ingredients Moldability Natural products Solubility Thixotropy |
| title | Dynamic covalent hydrogel of natural product baicalin with antibacterial activities |
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