A simple approach to prepare fluorescent molecularly imprinted nanoparticles
Fluorescent molecularly imprinted polymers (FMIPs) are gaining increasing attention in analytical and medical sciences, particularly silica-based FMIPs due to their low cost, environmentally friendly nature and good biocompatibility. However, at present, silica-based FMIPs are usually prepared throu...
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| Veröffentlicht in: | RSC advances 2021-02, Vol.11 (13), p.7732-7737 |
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| creator | Wang, Fenying Wang, Dan Wang, Tingting Jin, Yu Ling, Baoping Li, Qianjin Li, Jianlin |
| description | Fluorescent molecularly imprinted polymers (FMIPs) are gaining increasing attention in analytical and medical sciences, particularly silica-based FMIPs due to their low cost, environmentally friendly nature and good biocompatibility. However, at present, silica-based FMIPs are usually prepared through several steps and displayed low selectivity. Here, a simple approach was utilized for preparing silica-based FMIP nanoparticles. The polymerization was initiated by 3-aminopropyltriethoxysilane (APTES), which also acted as the functional monomer in the imprinting system; in addition, to achieve one-pot synthesis, a fluorescent monomer was prepared by a simple reaction between fluorescein isothiocyanate (FITC) and APTES. The as-synthesized FMIP nanoparticles displayed high specificity and fast response time ( |
| doi_str_mv | 10.1039/d0ra10618f |
| format | Article |
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Fluorescent molecularly imprinted polymer (FMIP) gains great attention in many fields due to their low cost, good biocompatibility and low toxicity. Here, a high-performance FMIP was prepared based on the autocatalytic silica sol-gel reaction.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d0ra10618f</identifier><identifier>PMID: 35423232</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aminopropyltriethoxysilane ; Biocompatibility ; Chemistry ; Fluorescein ; Fluorescence ; Imprinted polymers ; Monomers ; Nanoparticles ; Response time ; Selectivity ; Silicon dioxide</subject><ispartof>RSC advances, 2021-02, Vol.11 (13), p.7732-7737</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2021</rights><rights>This journal is © The Royal Society of Chemistry 2021 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-c7ec37c85a34e0959974389f41a86aaf310c16396d56b93cecad82c1576ad29f3</citedby><cites>FETCH-LOGICAL-c428t-c7ec37c85a34e0959974389f41a86aaf310c16396d56b93cecad82c1576ad29f3</cites><orcidid>0000-0001-5033-3514 ; 0000-0002-6498-7284</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694954/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694954/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35423232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fenying</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><creatorcontrib>Jin, Yu</creatorcontrib><creatorcontrib>Ling, Baoping</creatorcontrib><creatorcontrib>Li, Qianjin</creatorcontrib><creatorcontrib>Li, Jianlin</creatorcontrib><title>A simple approach to prepare fluorescent molecularly imprinted nanoparticles</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Fluorescent molecularly imprinted polymers (FMIPs) are gaining increasing attention in analytical and medical sciences, particularly silica-based FMIPs due to their low cost, environmentally friendly nature and good biocompatibility. However, at present, silica-based FMIPs are usually prepared through several steps and displayed low selectivity. Here, a simple approach was utilized for preparing silica-based FMIP nanoparticles. The polymerization was initiated by 3-aminopropyltriethoxysilane (APTES), which also acted as the functional monomer in the imprinting system; in addition, to achieve one-pot synthesis, a fluorescent monomer was prepared by a simple reaction between fluorescein isothiocyanate (FITC) and APTES. The as-synthesized FMIP nanoparticles displayed high specificity and fast response time (<1 min) towards the target molecule. Environmental pH and buffer salt could affect the specific recognition behaviors of the FMIP nanoparticles. Such a simple catalyst-free synthetic technique could also be employed for the preparation of FMIP nanoparticles targeting other acidic molecules.
Fluorescent molecularly imprinted polymer (FMIP) gains great attention in many fields due to their low cost, good biocompatibility and low toxicity. Here, a high-performance FMIP was prepared based on the autocatalytic silica sol-gel reaction.</description><subject>Aminopropyltriethoxysilane</subject><subject>Biocompatibility</subject><subject>Chemistry</subject><subject>Fluorescein</subject><subject>Fluorescence</subject><subject>Imprinted polymers</subject><subject>Monomers</subject><subject>Nanoparticles</subject><subject>Response time</subject><subject>Selectivity</subject><subject>Silicon dioxide</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLxDAUhYMoKuNs3CsFNyKM5t1mIwzjEwYE0XW4pqlW0qYmreC_N-OM4yN3kcD97uHcHIT2CT4lmKmzEgcgWJKi2kC7FHM5oViqzV_vHTSO8RWnIwWhkmyjHSY4Zal20XyaxbrpnM2g64IH85L1PuuC7SDYrHKDDzYa2_ZZ4501g4PgPrI0Eeq2t2XWQusT2tfG2biHtipw0Y5X9wg9Xl0-zG4m87vr29l0PjGcFv3E5Naw3BQCGLdYCaVyzgpVcQKFBKgYwYZIpmQp5JNixhooC2qIyCWUVFVshM6Xut3w1NhyYS-A08lTA-FDe6j1305bv-hn_64LqbgSPAkcrwSCfxts7HVTpy2dg9b6IWqafkoqQnCe0KN_6KsfQpvW05QrTChVRCTqZEmZ4GMMtlqbIVgvctIX-H76ldNVgg9_21-j36kk4GAJhGjW3Z-g2SdrXpg4</recordid><startdate>20210217</startdate><enddate>20210217</enddate><creator>Wang, Fenying</creator><creator>Wang, Dan</creator><creator>Wang, Tingting</creator><creator>Jin, Yu</creator><creator>Ling, Baoping</creator><creator>Li, Qianjin</creator><creator>Li, Jianlin</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5033-3514</orcidid><orcidid>https://orcid.org/0000-0002-6498-7284</orcidid></search><sort><creationdate>20210217</creationdate><title>A simple approach to prepare fluorescent molecularly imprinted nanoparticles</title><author>Wang, Fenying ; Wang, Dan ; Wang, Tingting ; Jin, Yu ; Ling, Baoping ; Li, Qianjin ; Li, Jianlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-c7ec37c85a34e0959974389f41a86aaf310c16396d56b93cecad82c1576ad29f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aminopropyltriethoxysilane</topic><topic>Biocompatibility</topic><topic>Chemistry</topic><topic>Fluorescein</topic><topic>Fluorescence</topic><topic>Imprinted polymers</topic><topic>Monomers</topic><topic>Nanoparticles</topic><topic>Response time</topic><topic>Selectivity</topic><topic>Silicon dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fenying</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><creatorcontrib>Jin, Yu</creatorcontrib><creatorcontrib>Ling, Baoping</creatorcontrib><creatorcontrib>Li, Qianjin</creatorcontrib><creatorcontrib>Li, Jianlin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fenying</au><au>Wang, Dan</au><au>Wang, Tingting</au><au>Jin, Yu</au><au>Ling, Baoping</au><au>Li, Qianjin</au><au>Li, Jianlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A simple approach to prepare fluorescent molecularly imprinted nanoparticles</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2021-02-17</date><risdate>2021</risdate><volume>11</volume><issue>13</issue><spage>7732</spage><epage>7737</epage><pages>7732-7737</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Fluorescent molecularly imprinted polymers (FMIPs) are gaining increasing attention in analytical and medical sciences, particularly silica-based FMIPs due to their low cost, environmentally friendly nature and good biocompatibility. However, at present, silica-based FMIPs are usually prepared through several steps and displayed low selectivity. Here, a simple approach was utilized for preparing silica-based FMIP nanoparticles. The polymerization was initiated by 3-aminopropyltriethoxysilane (APTES), which also acted as the functional monomer in the imprinting system; in addition, to achieve one-pot synthesis, a fluorescent monomer was prepared by a simple reaction between fluorescein isothiocyanate (FITC) and APTES. The as-synthesized FMIP nanoparticles displayed high specificity and fast response time (<1 min) towards the target molecule. Environmental pH and buffer salt could affect the specific recognition behaviors of the FMIP nanoparticles. Such a simple catalyst-free synthetic technique could also be employed for the preparation of FMIP nanoparticles targeting other acidic molecules.
Fluorescent molecularly imprinted polymer (FMIP) gains great attention in many fields due to their low cost, good biocompatibility and low toxicity. Here, a high-performance FMIP was prepared based on the autocatalytic silica sol-gel reaction.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35423232</pmid><doi>10.1039/d0ra10618f</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5033-3514</orcidid><orcidid>https://orcid.org/0000-0002-6498-7284</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aminopropyltriethoxysilane Biocompatibility Chemistry Fluorescein Fluorescence Imprinted polymers Monomers Nanoparticles Response time Selectivity Silicon dioxide |
| title | A simple approach to prepare fluorescent molecularly imprinted nanoparticles |
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