Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis

Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality. We previously reported increased ubiquitin-specific peptidase 18 (USP18) expression in lung and other cancers. Engineered r...

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Veröffentlicht in:	Cancer biology & therapy 2022-12, Vol.23 (1), p.265-280
Hauptverfasser:	Chen, Zibo, Zheng, Lin, Chen, Yulong, Liu, Xiuxia, Kawakami, Masanori, Mustachio, Lisa Maria, Roszik, Jason, Ferry-Galow, Katherine V., Parchment, Ralph E., Liu, Xin, Andresson, Thorkell, Duncan, Gerard, Kurie, Jonathan M., Rodriguez-Canales, Jaime, Liu, Xi, Dmitrovsky, Ethan
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism 14-3-3ζ Adenocarcinoma of Lung Animals Deubiquitinase Humans lung cancer and metastasis Lung Neoplasms - pathology Mice Research Paper Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitin-Specific Proteases - metabolism USP18
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