High mortality due to gastrointestinal TB in HIV and non-HIV patients
BACKGROUND: Due to the reported low incidence of gastrointestinal TB, there is a lack of data related to the prognosis, risk factors and frequency of resistant TB in this subgroup of patients.OBJECTIVE: To report the clinical presentation, diagnostic methods, treatment and outcomes in gastrointestin...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2022-04, Vol.26 (4), p.348-355 |
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| creator | Monreal-Robles, R. González-González, J. A. Sordia-Ramírez, J. Ruiz-Holguin, E. Negreros-Osuna, A. A. de la Rosa-Pacheco, S. Soto-Moncivais, B. Rendón, A. |
| description | BACKGROUND: Due to the reported low incidence of gastrointestinal TB, there is a lack of data related to the prognosis, risk factors and frequency of resistant TB in this subgroup of patients.OBJECTIVE: To report the clinical presentation, diagnostic methods, treatment
and outcomes in gastrointestinal TB.METHODS: We prospectively studied the demographic, clinical, and paraclinical data of all consecutive gastrointestinal TB inpatients over an 8-year period.RESULTS: We identified gastrointestinal TB in 28 (3.5%) out of 799 inpatients
with TB infection. Seven patients (25%) were HIV-positive. Overall mortality was 35.7%, with the combined variable of haemoglobin |
| doi_str_mv | 10.5588/ijtld.21.0446 |
| format | Article |
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and outcomes in gastrointestinal TB.METHODS: We prospectively studied the demographic, clinical, and paraclinical data of all consecutive gastrointestinal TB inpatients over an 8-year period.RESULTS: We identified gastrointestinal TB in 28 (3.5%) out of 799 inpatients
with TB infection. Seven patients (25%) were HIV-positive. Overall mortality was 35.7%, with the combined variable of haemoglobin <12 g/dL and albumin <2.8 g/dL being independently associated with mortality (OR 25.7, 95% CI 1.405-471.1, P = 0.029). No difference in the need
for surgery (28.6% vs. 47.6%, P = 0.662), occurrence of septic shock (14.3 vs. 23.8%, P = 1.00) or mortality (14.3% vs. 42.9%, P = 0.364) was found between HIV and non-HIV patients.CONCLUSION: Gastrointestinal TB was rare among TB patients in Hospital Universitario
"Dr José E. González" (3.5%), but had a high mortality rate (35.7%). Clinical evolution, drug susceptibility patterns and outcomes were similar in HIV and non-HIV patients. In both groups, the combined haemoglobin and albumin variable on admission was clearly associated
with mortality.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.21.0446</identifier><identifier>PMID: 35351240</identifier><language>eng</language><publisher>France: International Union Against Tuberculosis and Lung Disease</publisher><subject>abdominal tuberculosis, HIV ; Albumin ; Albumins ; Extrapulmonary Tuberculosis ; Hemoglobin ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Hospital Mortality ; Human immunodeficiency virus ; Humans ; Incidence ; Inflammatory Bowel Disease ; Mortality ; Patients ; Resistance factors ; Retrospective Studies ; Risk analysis ; Risk Factors ; Septic shock ; Subgroups ; Tuberculosis ; Tuberculosis - mortality</subject><ispartof>The international journal of tuberculosis and lung disease, 2022-04, Vol.26 (4), p.348-355</ispartof><rights>Copyright International Union against Tuberculosis and Lung Disease (IUATLD) Apr 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35351240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monreal-Robles, R.</creatorcontrib><creatorcontrib>González-González, J. A.</creatorcontrib><creatorcontrib>Sordia-Ramírez, J.</creatorcontrib><creatorcontrib>Ruiz-Holguin, E.</creatorcontrib><creatorcontrib>Negreros-Osuna, A. A.</creatorcontrib><creatorcontrib>de la Rosa-Pacheco, S.</creatorcontrib><creatorcontrib>Soto-Moncivais, B.</creatorcontrib><creatorcontrib>Rendón, A.</creatorcontrib><title>High mortality due to gastrointestinal TB in HIV and non-HIV patients</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>BACKGROUND: Due to the reported low incidence of gastrointestinal TB, there is a lack of data related to the prognosis, risk factors and frequency of resistant TB in this subgroup of patients.OBJECTIVE: To report the clinical presentation, diagnostic methods, treatment
and outcomes in gastrointestinal TB.METHODS: We prospectively studied the demographic, clinical, and paraclinical data of all consecutive gastrointestinal TB inpatients over an 8-year period.RESULTS: We identified gastrointestinal TB in 28 (3.5%) out of 799 inpatients
with TB infection. Seven patients (25%) were HIV-positive. Overall mortality was 35.7%, with the combined variable of haemoglobin <12 g/dL and albumin <2.8 g/dL being independently associated with mortality (OR 25.7, 95% CI 1.405-471.1, P = 0.029). No difference in the need
for surgery (28.6% vs. 47.6%, P = 0.662), occurrence of septic shock (14.3 vs. 23.8%, P = 1.00) or mortality (14.3% vs. 42.9%, P = 0.364) was found between HIV and non-HIV patients.CONCLUSION: Gastrointestinal TB was rare among TB patients in Hospital Universitario
"Dr José E. González" (3.5%), but had a high mortality rate (35.7%). Clinical evolution, drug susceptibility patterns and outcomes were similar in HIV and non-HIV patients. In both groups, the combined haemoglobin and albumin variable on admission was clearly associated
with mortality.</description><subject>abdominal tuberculosis, HIV</subject><subject>Albumin</subject><subject>Albumins</subject><subject>Extrapulmonary Tuberculosis</subject><subject>Hemoglobin</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Hospital Mortality</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Incidence</subject><subject>Inflammatory Bowel Disease</subject><subject>Mortality</subject><subject>Patients</subject><subject>Resistance factors</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Septic shock</subject><subject>Subgroups</subject><subject>Tuberculosis</subject><subject>Tuberculosis - mortality</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFrFDEUh4NUbK0evZZAL15mfS-TTGaOba1uoSBC9RrSJLPNMpvZJhmh_vVmdrcVBHN5j_Dx5eX3CPmAsBCibT_5dR7sguECOG9ekRNsUVSyY3BUemCyqiV2x-RtSmsAhojyDTmuRS2QcTgh10u_eqCbMWY9-PxE7eRoHulKpxxHH7JL2Qc90LtL6gNd3vykOlgaxlDN_VZn70JO78jrXg_JvT_UU_Ljy_Xd1bK6_fb15uritjIcWa7q1lrZC3cvLZiGdwZBGIPSCO54uWKt7YAB63rkGpreApeStUZI6TrsZH1KPu692zg-TmU2tfHJuGHQwY1TUqzhgksUrSjo-T_oepxi-cqOagDausZCVXvKxDGl6Hq1jX6j45NCUHO-apevYqjmfAt_drBO9xtnX-jnQAvweQ_4sCrJ6L-v-knPpoMPGFOwO6w5NMCVjrlUnDXf_6cxz6Z5u_Ny1S_WBL5TgoSuDFqjsq7X05BV1lGtfqtUnH8AkCCk_A</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Monreal-Robles, R.</creator><creator>González-González, J. A.</creator><creator>Sordia-Ramírez, J.</creator><creator>Ruiz-Holguin, E.</creator><creator>Negreros-Osuna, A. A.</creator><creator>de la Rosa-Pacheco, S.</creator><creator>Soto-Moncivais, B.</creator><creator>Rendón, A.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease (IUATLD)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20220401</creationdate><title>High mortality due to gastrointestinal TB in HIV and non-HIV patients</title><author>Monreal-Robles, R. ; González-González, J. A. ; Sordia-Ramírez, J. ; Ruiz-Holguin, E. ; Negreros-Osuna, A. A. ; de la Rosa-Pacheco, S. ; Soto-Moncivais, B. ; Rendón, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-38dd7f5eb7d0c649c105cc17c54e4d0c28d902029f14a06fd047728c577e91973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>abdominal tuberculosis, HIV</topic><topic>Albumin</topic><topic>Albumins</topic><topic>Extrapulmonary Tuberculosis</topic><topic>Hemoglobin</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Hospital Mortality</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Incidence</topic><topic>Inflammatory Bowel Disease</topic><topic>Mortality</topic><topic>Patients</topic><topic>Resistance factors</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Septic shock</topic><topic>Subgroups</topic><topic>Tuberculosis</topic><topic>Tuberculosis - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monreal-Robles, R.</creatorcontrib><creatorcontrib>González-González, J. A.</creatorcontrib><creatorcontrib>Sordia-Ramírez, J.</creatorcontrib><creatorcontrib>Ruiz-Holguin, E.</creatorcontrib><creatorcontrib>Negreros-Osuna, A. A.</creatorcontrib><creatorcontrib>de la Rosa-Pacheco, S.</creatorcontrib><creatorcontrib>Soto-Moncivais, B.</creatorcontrib><creatorcontrib>Rendón, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monreal-Robles, R.</au><au>González-González, J. A.</au><au>Sordia-Ramírez, J.</au><au>Ruiz-Holguin, E.</au><au>Negreros-Osuna, A. A.</au><au>de la Rosa-Pacheco, S.</au><au>Soto-Moncivais, B.</au><au>Rendón, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High mortality due to gastrointestinal TB in HIV and non-HIV patients</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>26</volume><issue>4</issue><spage>348</spage><epage>355</epage><pages>348-355</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>BACKGROUND: Due to the reported low incidence of gastrointestinal TB, there is a lack of data related to the prognosis, risk factors and frequency of resistant TB in this subgroup of patients.OBJECTIVE: To report the clinical presentation, diagnostic methods, treatment
and outcomes in gastrointestinal TB.METHODS: We prospectively studied the demographic, clinical, and paraclinical data of all consecutive gastrointestinal TB inpatients over an 8-year period.RESULTS: We identified gastrointestinal TB in 28 (3.5%) out of 799 inpatients
with TB infection. Seven patients (25%) were HIV-positive. Overall mortality was 35.7%, with the combined variable of haemoglobin <12 g/dL and albumin <2.8 g/dL being independently associated with mortality (OR 25.7, 95% CI 1.405-471.1, P = 0.029). No difference in the need
for surgery (28.6% vs. 47.6%, P = 0.662), occurrence of septic shock (14.3 vs. 23.8%, P = 1.00) or mortality (14.3% vs. 42.9%, P = 0.364) was found between HIV and non-HIV patients.CONCLUSION: Gastrointestinal TB was rare among TB patients in Hospital Universitario
"Dr José E. González" (3.5%), but had a high mortality rate (35.7%). Clinical evolution, drug susceptibility patterns and outcomes were similar in HIV and non-HIV patients. In both groups, the combined haemoglobin and albumin variable on admission was clearly associated
with mortality.</abstract><cop>France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>35351240</pmid><doi>10.5588/ijtld.21.0446</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | abdominal tuberculosis, HIV Albumin Albumins Extrapulmonary Tuberculosis Hemoglobin HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Hospital Mortality Human immunodeficiency virus Humans Incidence Inflammatory Bowel Disease Mortality Patients Resistance factors Retrospective Studies Risk analysis Risk Factors Septic shock Subgroups Tuberculosis Tuberculosis - mortality |
| title | High mortality due to gastrointestinal TB in HIV and non-HIV patients |
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