TransPPMP: Predicting pathogenicity of frameshift and nonsense mutations by a transformer based on protein features

Protein structure can be severely disrupted by frameshift and nonsense mutations at specific positions in the protein sequence. Frameshift and nonsense mutation cases can also be found in healthy individuals. A method to distinguish neutral and potentially disease-associated frameshift and nonsense...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2022-03
Hauptverfasser:	Nie, Liangpeng, Quan, Lijun, Wu, Tingfang, He, Ruji, Lyu, Qiang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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