In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D 3 , and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network

Chemoresistance to 5-fluorouracil (5-FU) is common during colorectal cancer (CRC) treatment. This study measured the chemotherapeutic effects of 5-FU, active vitamin D (VD ), and/or metformin single/dual/triple regimens as complementary/alternative therapies. Ninety male mice were divided into: nega...

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Veröffentlicht in:	Cancers 2022-03, Vol.14 (6)
Hauptverfasser:	Almaimani, Riyad Adnan, Aslam, Akhmed, Ahmad, Jawwad, El-Readi, Mahmoud Zaki, El-Boshy, Mohamed E, Abdelghany, Abdelghany H, Idris, Shakir, Alhadrami, Mai, Althubiti, Mohammad, Almasmoum, Hussain A, Ghaith, Mazen M, Elzubeir, Mohamed E, Eid, Safaa Yehia, Refaat, Bassem
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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