Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature

Pulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular remodeling that includes increased muscularization of distal blood vessels and vessel stiffening associated with changes in extracellular matrix d...

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Veröffentlicht in:	Journal of vascular research 2022-05, Vol.59 (3), p.163-175
Hauptverfasser:	Thomas, Shelby, Manivannan, Sathiyanarayanan, Garg, Vidu, Lilly, Brenda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Complications and side effects Development and progression Genetic aspects Genetic transcription Health aspects Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypoxia Hypoxia - complications Lung Mice Muscle, Smooth, Vascular - metabolism Pulmonary Arterial Hypertension Pulmonary Artery - metabolism Pulmonary hypertension Research Article RNA sequencing Sequence Analysis, RNA Vascular smooth muscle
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