1- and 4-Week Cimetidine Treatment for Duodenal Ulcer
Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (CI+P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. E...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1986, Vol.21 (6), p.701-704 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Johannessen, T. Kristensen, P. Fjøsne, U. Hafstad, P. E. Kleveland, P. M. Løge, I. Sandbakken, P. Petersen, H. |
| description | Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (CI+P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed after 4 weeks. Two patients receiving C1+P dropped out during the 2nd week because of worsening symptoms. With the two dropouts being recorded as 'unhealed ulcers', the 4-week healing rates were 16 of 24 (67%) and 15 of 24 (63%), with C4 and Cl+P, respectively (p < 0.05). Even without including the two dropouts, the patients treated with C1+P had significantly more symptoms during the 2nd and 3rd treatment week than those treated with C4. The present study indicates that 1 week of cimetidine treatment is not sufficient in patients with duodenal ulcer. |
| doi_str_mv | 10.3109/00365528609011103 |
| format | Article |
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Even without including the two dropouts, the patients treated with C1+P had significantly more symptoms during the 2nd and 3rd treatment week than those treated with C4. The present study indicates that 1 week of cimetidine treatment is not sufficient in patients with duodenal ulcer.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365528609011103</identifier><identifier>PMID: 3529360</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Cimetidine ; Cimetidine - administration & dosage ; Clinical Trials as Topic ; Digestive system ; Double-Blind Method ; Drug Administration Schedule ; duodenal ulcer ; Duodenal Ulcer - drug therapy ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Random Allocation ; treatment duration</subject><ispartof>Scandinavian journal of gastroenterology, 1986, Vol.21 (6), p.701-704</ispartof><rights>1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-fcb9af93a87e0e2f524179e644d9f5b23ac6831fe3a04eae8a0ceba8974881ac3</citedby><cites>FETCH-LOGICAL-c345t-fcb9af93a87e0e2f524179e644d9f5b23ac6831fe3a04eae8a0ceba8974881ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365528609011103$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365528609011103$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8010552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3529360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johannessen, T.</creatorcontrib><creatorcontrib>Kristensen, P.</creatorcontrib><creatorcontrib>Fjøsne, U.</creatorcontrib><creatorcontrib>Hafstad, P. E.</creatorcontrib><creatorcontrib>Kleveland, P. M.</creatorcontrib><creatorcontrib>Løge, I.</creatorcontrib><creatorcontrib>Sandbakken, P.</creatorcontrib><creatorcontrib>Petersen, H.</creatorcontrib><title>1- and 4-Week Cimetidine Treatment for Duodenal Ulcer</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (CI+P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed after 4 weeks. Two patients receiving C1+P dropped out during the 2nd week because of worsening symptoms. With the two dropouts being recorded as 'unhealed ulcers', the 4-week healing rates were 16 of 24 (67%) and 15 of 24 (63%), with C4 and Cl+P, respectively (p < 0.05). Even without including the two dropouts, the patients treated with C1+P had significantly more symptoms during the 2nd and 3rd treatment week than those treated with C4. The present study indicates that 1 week of cimetidine treatment is not sufficient in patients with duodenal ulcer.</description><subject>Biological and medical sciences</subject><subject>Cimetidine</subject><subject>Cimetidine - administration & dosage</subject><subject>Clinical Trials as Topic</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>duodenal ulcer</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>treatment duration</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAURUVoSCaT_IAuCl6U7pw-WZItkW7CtPmAgWwmZGneyE-Mp7KdSDZl_n0VZhoIhay0uOde9A5jnzlcCg7mO4AolSp0CQY45yCO2IwrKPKqAv2JzV7zPAH8lJ3FuAUAVUlzwk6EKowoYcYUzzPsm0zmT0S_s0Xb0dg2bU_ZKhCOHfVj5oaQ_ZyGhnr02aO3FM7ZsUMf6eLwztnjza_V4i5fPtzeL66XuRVSjbmza4POCNQVARVOFZJXhkopG-PUuhBoSy24I4EgCUkjWFqjNpXUmqMVc_Ztv_schpeJ4lh3bbTkPfY0TLFOZxZKVkUC-R60YYgxkKufQ9th2NUc6ldV9X-qUufLYXxad9S8NQ5uUv71kGO06F3A3rbxDdPAIQ0m7Mcea_skqsM_Q_BNPeLOD-FfR3z0i6t39Q2hHzcWA9XbYQpJefzghr8zCJN4</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Johannessen, T.</creator><creator>Kristensen, P.</creator><creator>Fjøsne, U.</creator><creator>Hafstad, P. E.</creator><creator>Kleveland, P. M.</creator><creator>Løge, I.</creator><creator>Sandbakken, P.</creator><creator>Petersen, H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>1- and 4-Week Cimetidine Treatment for Duodenal Ulcer</title><author>Johannessen, T. ; Kristensen, P. ; Fjøsne, U. ; Hafstad, P. E. ; Kleveland, P. M. ; Løge, I. ; Sandbakken, P. ; Petersen, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-fcb9af93a87e0e2f524179e644d9f5b23ac6831fe3a04eae8a0ceba8974881ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Biological and medical sciences</topic><topic>Cimetidine</topic><topic>Cimetidine - administration & dosage</topic><topic>Clinical Trials as Topic</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>duodenal ulcer</topic><topic>Duodenal Ulcer - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>treatment duration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johannessen, T.</creatorcontrib><creatorcontrib>Kristensen, P.</creatorcontrib><creatorcontrib>Fjøsne, U.</creatorcontrib><creatorcontrib>Hafstad, P. E.</creatorcontrib><creatorcontrib>Kleveland, P. M.</creatorcontrib><creatorcontrib>Løge, I.</creatorcontrib><creatorcontrib>Sandbakken, P.</creatorcontrib><creatorcontrib>Petersen, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johannessen, T.</au><au>Kristensen, P.</au><au>Fjøsne, U.</au><au>Hafstad, P. E.</au><au>Kleveland, P. M.</au><au>Løge, I.</au><au>Sandbakken, P.</au><au>Petersen, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1- and 4-Week Cimetidine Treatment for Duodenal Ulcer</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1986</date><risdate>1986</risdate><volume>21</volume><issue>6</issue><spage>701</spage><epage>704</epage><pages>701-704</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (CI+P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed after 4 weeks. Two patients receiving C1+P dropped out during the 2nd week because of worsening symptoms. With the two dropouts being recorded as 'unhealed ulcers', the 4-week healing rates were 16 of 24 (67%) and 15 of 24 (63%), with C4 and Cl+P, respectively (p < 0.05). Even without including the two dropouts, the patients treated with C1+P had significantly more symptoms during the 2nd and 3rd treatment week than those treated with C4. The present study indicates that 1 week of cimetidine treatment is not sufficient in patients with duodenal ulcer.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>3529360</pmid><doi>10.3109/00365528609011103</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1986, Vol.21 (6), p.701-704 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Biological and medical sciences Cimetidine Cimetidine - administration & dosage Clinical Trials as Topic Digestive system Double-Blind Method Drug Administration Schedule duodenal ulcer Duodenal Ulcer - drug therapy Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Random Allocation treatment duration |
| title | 1- and 4-Week Cimetidine Treatment for Duodenal Ulcer |
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