Immunomodulatory effect of synthetic branched polypeptides. II
A comparative investigation of various polypeptides was carried out in order to elucidate structure-activity correlations. The immunoadjuvant properties of the chemically well-characterized branched polypeptides, poly[Lys-(DL-Alam)] (Lys:Ala = 1:2.95) (AK), poly[Lys-(D-Leui-DL-Alam)] (Lys:Ala:Leu =...
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| Veröffentlicht in: | Journal of biological response modifiers 1986-04, Vol.5 (2), p.148 |
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| creator | Gaál, D Hudecz, F Kovács, A L Szekerke, M |
| description | A comparative investigation of various polypeptides was carried out in order to elucidate structure-activity correlations. The immunoadjuvant properties of the chemically well-characterized branched polypeptides, poly[Lys-(DL-Alam)] (Lys:Ala = 1:2.95) (AK), poly[Lys-(D-Leui-DL-Alam)] (Lys:Ala:Leu = 1:3.0:0.95) (D-LAK), and poly[Lys-Hisi-DL-Alam)] (Lys:Ala:His = 1:2.95:0.85) (HAK), were investigated. D-LAK and HAK were able to augment the antibody response of BDF inbred mice to immunization with sheep red blood cells (SRBC), as assessed by the hemolytic plaque-forming cell assay, whereas AK had no similar effect. The stimulating effect of D-LAK and HAK was dependent on dose and timing of treatment relative to SRBC immunization. However, the optimal dose levels were lower and the effective dose interval more restricted as compared to the previously described poly[Lys-(Leui-DL-Alam)] (LAK). Like LAK, both HAK and D-LAK were able to compensate for the immunosuppressive effect of the cytotoxic drugs dianhydrogalactitol, vincristine, and 5-fluorouracil, which all have different mechanisms of action, provided that combined treatment by polypeptide and drug was applied repeatedly before the SRBC immunization. |
| format | Article |
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However, the optimal dose levels were lower and the effective dose interval more restricted as compared to the previously described poly[Lys-(Leui-DL-Alam)] (LAK). Like LAK, both HAK and D-LAK were able to compensate for the immunosuppressive effect of the cytotoxic drugs dianhydrogalactitol, vincristine, and 5-fluorouracil, which all have different mechanisms of action, provided that combined treatment by polypeptide and drug was applied repeatedly before the SRBC immunization.</description><identifier>ISSN: 0732-6580</identifier><identifier>PMID: 3525762</identifier><language>eng</language><publisher>United States</publisher><subject>Adjuvants, Immunologic - chemical synthesis ; Adjuvants, Immunologic - immunology ; Adjuvants, Immunologic - toxicity ; Animals ; Antibody Formation ; Antineoplastic Agents - toxicity ; Dose-Response Relationship, Drug ; Hemolytic Plaque Technique ; Immunologic Deficiency Syndromes - chemically induced ; Immunologic Deficiency Syndromes - prevention & control ; Liver - cytology ; Liver - drug effects ; Mice ; Molecular Conformation ; Peptides - chemical synthesis ; Peptides - immunology ; Peptides - toxicity ; Rosette Formation ; Spleen - cytology ; Spleen - drug effects ; Structure-Activity Relationship</subject><ispartof>Journal of biological response modifiers, 1986-04, Vol.5 (2), p.148</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3525762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaál, D</creatorcontrib><creatorcontrib>Hudecz, F</creatorcontrib><creatorcontrib>Kovács, A L</creatorcontrib><creatorcontrib>Szekerke, M</creatorcontrib><title>Immunomodulatory effect of synthetic branched polypeptides. II</title><title>Journal of biological response modifiers</title><addtitle>J Biol Response Mod</addtitle><description>A comparative investigation of various polypeptides was carried out in order to elucidate structure-activity correlations. The immunoadjuvant properties of the chemically well-characterized branched polypeptides, poly[Lys-(DL-Alam)] (Lys:Ala = 1:2.95) (AK), poly[Lys-(D-Leui-DL-Alam)] (Lys:Ala:Leu = 1:3.0:0.95) (D-LAK), and poly[Lys-Hisi-DL-Alam)] (Lys:Ala:His = 1:2.95:0.85) (HAK), were investigated. D-LAK and HAK were able to augment the antibody response of BDF inbred mice to immunization with sheep red blood cells (SRBC), as assessed by the hemolytic plaque-forming cell assay, whereas AK had no similar effect. The stimulating effect of D-LAK and HAK was dependent on dose and timing of treatment relative to SRBC immunization. However, the optimal dose levels were lower and the effective dose interval more restricted as compared to the previously described poly[Lys-(Leui-DL-Alam)] (LAK). 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II</title><author>Gaál, D ; Hudecz, F ; Kovács, A L ; Szekerke, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-c19df9bc138d6e701747ab3ea7928777d378cb182597310bd4d8165145d815573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adjuvants, Immunologic - chemical synthesis</topic><topic>Adjuvants, Immunologic - immunology</topic><topic>Adjuvants, Immunologic - toxicity</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hemolytic Plaque Technique</topic><topic>Immunologic Deficiency Syndromes - chemically induced</topic><topic>Immunologic Deficiency Syndromes - prevention & control</topic><topic>Liver - cytology</topic><topic>Liver - drug effects</topic><topic>Mice</topic><topic>Molecular Conformation</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - immunology</topic><topic>Peptides - toxicity</topic><topic>Rosette Formation</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>Structure-Activity Relationship</topic><toplevel>online_resources</toplevel><creatorcontrib>Gaál, D</creatorcontrib><creatorcontrib>Hudecz, F</creatorcontrib><creatorcontrib>Kovács, A L</creatorcontrib><creatorcontrib>Szekerke, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of biological response modifiers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaál, D</au><au>Hudecz, F</au><au>Kovács, A L</au><au>Szekerke, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory effect of synthetic branched polypeptides. II</atitle><jtitle>Journal of biological response modifiers</jtitle><addtitle>J Biol Response Mod</addtitle><date>1986-04</date><risdate>1986</risdate><volume>5</volume><issue>2</issue><spage>148</spage><pages>148-</pages><issn>0732-6580</issn><abstract>A comparative investigation of various polypeptides was carried out in order to elucidate structure-activity correlations. The immunoadjuvant properties of the chemically well-characterized branched polypeptides, poly[Lys-(DL-Alam)] (Lys:Ala = 1:2.95) (AK), poly[Lys-(D-Leui-DL-Alam)] (Lys:Ala:Leu = 1:3.0:0.95) (D-LAK), and poly[Lys-Hisi-DL-Alam)] (Lys:Ala:His = 1:2.95:0.85) (HAK), were investigated. D-LAK and HAK were able to augment the antibody response of BDF inbred mice to immunization with sheep red blood cells (SRBC), as assessed by the hemolytic plaque-forming cell assay, whereas AK had no similar effect. The stimulating effect of D-LAK and HAK was dependent on dose and timing of treatment relative to SRBC immunization. However, the optimal dose levels were lower and the effective dose interval more restricted as compared to the previously described poly[Lys-(Leui-DL-Alam)] (LAK). Like LAK, both HAK and D-LAK were able to compensate for the immunosuppressive effect of the cytotoxic drugs dianhydrogalactitol, vincristine, and 5-fluorouracil, which all have different mechanisms of action, provided that combined treatment by polypeptide and drug was applied repeatedly before the SRBC immunization.</abstract><cop>United States</cop><pmid>3525762</pmid></addata></record> |
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| ispartof | Journal of biological response modifiers, 1986-04, Vol.5 (2), p.148 |
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| language | eng |
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| subjects | Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - immunology Adjuvants, Immunologic - toxicity Animals Antibody Formation Antineoplastic Agents - toxicity Dose-Response Relationship, Drug Hemolytic Plaque Technique Immunologic Deficiency Syndromes - chemically induced Immunologic Deficiency Syndromes - prevention & control Liver - cytology Liver - drug effects Mice Molecular Conformation Peptides - chemical synthesis Peptides - immunology Peptides - toxicity Rosette Formation Spleen - cytology Spleen - drug effects Structure-Activity Relationship |
| title | Immunomodulatory effect of synthetic branched polypeptides. II |
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