Self-immolative polyplexes for DNA delivery

Nucleic acids have immense potential for the treatment and prevention of a wide range of diseases, but delivery vehicles are needed to assist with their entry into cells. Polycations can reversibly complex with nucleic acids via ionic interactions to form polyplexes and transport them into cells, bu...

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Veröffentlicht in:	Biomaterials science 2022-05, Vol.1 (1), p.2557-2567
Hauptverfasser:	Sirianni, Quinton E. A, Wang, TianDuo, Borecki, Aneta, Deng, Zhengyu, Ronald, John A, Gillies, Elizabeth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Cations Commercial aircraft Cytotoxicity Depolymerization Gene expression Ionic interactions Nanoparticles Nucleic acids Plasmids Polyelectrolytes Polyethyleneimine Toxicity
Online-Zugang:	Volltext
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