Mortality Predictive Value of the C 2 HEST Score in Elderly Subjects with COVID-19-A Subanalysis of the COLOS Study

Senility has been identified among the strongest risk predictors for unfavorable COVID-19-outcome. However, even in the elderly population, the clinical course of infection in individual patients remains unpredictable. Hence, there is an urgent need for developing a simple tool predicting adverse COVID-19-outcomes. We assumed that the C2HEST-score could predict unfavorable clinical outcomes in the elderly subjects with COVID-19-subjects. We retrospectively analyzed 1047 medical records of patients at age > 65 years, hospitalized at the medical university center due to COVID-19. Subsequently, patients were divided into three categories depending on their C2HEST-score result. We noticed significant differences in the and 3- and 6- mortality-which was the highest in - -C2HEST-stratum reaching 35.7%, 54.4%, and 65.9%, respectively. The -stratum mortalities reached 24.1% 43.4%, and 57.6% and for -stratum 14.4%, 25.8%, and 39.2% respectively. In the C2HEST-score model, a change from the to the category increased the probability of death intensity approximately two-times. Subsequently, transfer from the to the -stratum raised all-cause-death-intensity 2.7-times. Analysis of the secondary outcomes revealed that the C2HEST-score has predictive value for acute kidney injury, acute heart failure, and cardiogenic shock. C2HEST-score analysis on admission to the hospital may predict the mortality, acute kidney injury, and acute heart failure in elderly subjects with COVID-19.