Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway

The osteogenic potential of the human dental pulp stromal cells (hDPSCs) was reduced in the state of oxidative stress. Resveratrol (RSV) possesses numerous biological properties, including osteogenic potential, growth-promoting and antioxidant activities. This study investigates the osteogenic poten...

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Veröffentlicht in:	Pharmaceutical biology 2022-12, Vol.60 (1), p.501-508
Hauptverfasser:	Zhang, Jingying, Li, Rui, Man, Kenny, Yang, Xuebin B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alkaline phosphatase Animals Animals, Outbred Strains Antioxidants Bone growth Bone matrix Bone surgery Cbfa-1 protein Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen Computed tomography Dental pulp Dental Pulp - cytology Dental pulp stromal cell Diabetes mellitus Enzymatic activity Enzymes Female Gene expression Glutathione Heart diseases Humans Immunofluorescence Labeling Mice NF-E2-Related Factor 2 - metabolism OCN Osteogenesis - drug effects Oxidative stress Oxidative Stress - drug effects Polymerase chain reaction Reactive oxygen species Reactive Oxygen Species - metabolism Regenerative medicine Resveratrol Resveratrol - pharmacology ROS RUNX1 SIRT1 protein Sirtuin 1 - metabolism skull defect SOD Stromal cells Stromal Cells - cytology Stromal Cells - drug effects Superoxide dismutase Superoxide Dismutase - metabolism xCT
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