Choroid plexus-selective inactivation of adenosine A 2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP), a key site for t...

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Veröffentlicht in:	Journal of neuroinflammation 2022-02, Vol.19 (1), p.52
Hauptverfasser:	Zheng, Wu, Feng, Yijia, Zeng, Zhenhai, Ye, Mengqian, Wang, Mengru, Liu, Xin, Tang, Ping, Shang, Huiping, Sun, Xiaoting, Lin, Xiangxiang, Wang, Muran, Li, Zhengzheng, Weng, Yiyun, Guo, Wei, Vakal, Sergii, Chen, Jiang-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Adenosine - therapeutic use Animals Choroid Plexus - metabolism Encephalomyelitis, Autoimmune, Experimental - metabolism Mice Mice, Inbred C57BL Receptor, Adenosine A2A - metabolism Receptor, Adenosine A2A - therapeutic use
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