Comparison of 2D planar and 3D volumetric methods for estimation of split renal function by 99m Tc-DMSA scintigraphy
Split renal function (SRF) can be measured by using several methods in Tc-DMSA scintigraphy. Geometric mean (GM) based methods derived from planar images(2D) have been used for several years, besides; 3D-methods were also reported as an option for assessment of SRF. The purpose of this study to comp...
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| Veröffentlicht in: | Physica medica 2022-03, Vol.95, p.83 |
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| creator | Civan, Caner Has Simsek, Duygu Kiran, Murat Yilmaz Isik, Emine Goknur Ozkan, Zeynep Gozde Sanli, Yasemin Kuyumcu, Serkan |
| description | Split renal function (SRF) can be measured by using several methods in
Tc-DMSA scintigraphy. Geometric mean (GM) based methods derived from planar images(2D) have been used for several years, besides; 3D-methods were also reported as an option for assessment of SRF. The purpose of this study to compare 2D and 3D methods for calculation of SRF in pediatric and adult patients.
We evaluated 212 patients, underwent both planar and SPECT
Tc-DMSA scintigraphy.2D-SRFs were calculated by GM without background correction (SRFnobcg), GM with background correction in crescent formation from lower lateral borders (SRFcres), and GM with background correction in circumferential formation, including the whole kidney surroundings (SRFcirc). In 3D settings, SRF was measured with SPECT (SRFspect). Paired t-test was used to compare the mean SRFs of each group. Bland-Altman method was used as an agreement method for each method. Analyses were performed based on left kidney SRFs.
In comparison of 2D and 3D methods, SRFspect was significantly different from SRFnobcg and SRFcres (p= |
| doi_str_mv | 10.1016/j.ejmp.2022.01.010 |
| format | Article |
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Tc-DMSA scintigraphy. Geometric mean (GM) based methods derived from planar images(2D) have been used for several years, besides; 3D-methods were also reported as an option for assessment of SRF. The purpose of this study to compare 2D and 3D methods for calculation of SRF in pediatric and adult patients.
We evaluated 212 patients, underwent both planar and SPECT
Tc-DMSA scintigraphy.2D-SRFs were calculated by GM without background correction (SRFnobcg), GM with background correction in crescent formation from lower lateral borders (SRFcres), and GM with background correction in circumferential formation, including the whole kidney surroundings (SRFcirc). In 3D settings, SRF was measured with SPECT (SRFspect). Paired t-test was used to compare the mean SRFs of each group. Bland-Altman method was used as an agreement method for each method. Analyses were performed based on left kidney SRFs.
In comparison of 2D and 3D methods, SRFspect was significantly different from SRFnobcg and SRFcres (p=<0.001) but not from SRFcirc (p = 0.155) in all patients. Similar results were found for patients with high creatinine level, SRFcirc and SRFspect were not significantly different (p = 0.317), while significant differences were found between SRFspect and SRFnobcg/SRFcres (p=<0.001).On the other hand, all 2D-methods showed statistical differences (p=<0.001-0.026) from 3D-method in pediatric patients. Bland-Altman-plot demonstrated that SRFcirc underestimated the poor functioning kidneys.
SRFcirc can be used in measurement of SRF in adult patients with normal functioning kidneys in busy clinics. However, SRFspect provides more accurate results and suggested particularly for pediatric patients and poor functioning kidneys.</description><identifier>EISSN: 1724-191X</identifier><identifier>DOI: 10.1016/j.ejmp.2022.01.010</identifier><identifier>PMID: 35134649</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Child ; Humans ; Kidney - diagnostic imaging ; Kidney - physiology ; Kidney Function Tests - methods ; Radionuclide Imaging ; Radiopharmaceuticals ; Technetium Tc 99m Dimercaptosuccinic Acid ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>Physica medica, 2022-03, Vol.95, p.83</ispartof><rights>Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35134649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Civan, Caner</creatorcontrib><creatorcontrib>Has Simsek, Duygu</creatorcontrib><creatorcontrib>Kiran, Murat Yilmaz</creatorcontrib><creatorcontrib>Isik, Emine Goknur</creatorcontrib><creatorcontrib>Ozkan, Zeynep Gozde</creatorcontrib><creatorcontrib>Sanli, Yasemin</creatorcontrib><creatorcontrib>Kuyumcu, Serkan</creatorcontrib><title>Comparison of 2D planar and 3D volumetric methods for estimation of split renal function by 99m Tc-DMSA scintigraphy</title><title>Physica medica</title><addtitle>Phys Med</addtitle><description>Split renal function (SRF) can be measured by using several methods in
Tc-DMSA scintigraphy. Geometric mean (GM) based methods derived from planar images(2D) have been used for several years, besides; 3D-methods were also reported as an option for assessment of SRF. The purpose of this study to compare 2D and 3D methods for calculation of SRF in pediatric and adult patients.
We evaluated 212 patients, underwent both planar and SPECT
Tc-DMSA scintigraphy.2D-SRFs were calculated by GM without background correction (SRFnobcg), GM with background correction in crescent formation from lower lateral borders (SRFcres), and GM with background correction in circumferential formation, including the whole kidney surroundings (SRFcirc). In 3D settings, SRF was measured with SPECT (SRFspect). Paired t-test was used to compare the mean SRFs of each group. Bland-Altman method was used as an agreement method for each method. Analyses were performed based on left kidney SRFs.
In comparison of 2D and 3D methods, SRFspect was significantly different from SRFnobcg and SRFcres (p=<0.001) but not from SRFcirc (p = 0.155) in all patients. Similar results were found for patients with high creatinine level, SRFcirc and SRFspect were not significantly different (p = 0.317), while significant differences were found between SRFspect and SRFnobcg/SRFcres (p=<0.001).On the other hand, all 2D-methods showed statistical differences (p=<0.001-0.026) from 3D-method in pediatric patients. Bland-Altman-plot demonstrated that SRFcirc underestimated the poor functioning kidneys.
SRFcirc can be used in measurement of SRF in adult patients with normal functioning kidneys in busy clinics. However, SRFspect provides more accurate results and suggested particularly for pediatric patients and poor functioning kidneys.</description><subject>Adult</subject><subject>Child</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiology</subject><subject>Kidney Function Tests - methods</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Technetium Tc 99m Dimercaptosuccinic Acid</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>1724-191X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjsmKwkAYhBtB3F_Ag_wvkNhLouQoZgYvcxoP3qRNOtqhN7o7Qt7eMMtZKPigqCoKoTXBKcFkt21T0WqXUkxpiskgPEIzsqdZQgpymaJ5CC3GjNI8n6ApywnLdlkxQ_FoteNeBmvANkBLcIob7oGbGlgJT6s6LaKXFQx42DpAYz2IEKXmUf62glMygheGK2g6U_34tx6KQsO5Ssqv7wOESpoo7567R79E44arIFZ_XKDN58f5eEpcd9Oivjo_jPv--n-TvQ28AJLDTrY</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Civan, Caner</creator><creator>Has Simsek, Duygu</creator><creator>Kiran, Murat Yilmaz</creator><creator>Isik, Emine Goknur</creator><creator>Ozkan, Zeynep Gozde</creator><creator>Sanli, Yasemin</creator><creator>Kuyumcu, Serkan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202203</creationdate><title>Comparison of 2D planar and 3D volumetric methods for estimation of split renal function by 99m Tc-DMSA scintigraphy</title><author>Civan, Caner ; Has Simsek, Duygu ; Kiran, Murat Yilmaz ; Isik, Emine Goknur ; Ozkan, Zeynep Gozde ; Sanli, Yasemin ; Kuyumcu, Serkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_351346493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Child</topic><topic>Humans</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiology</topic><topic>Kidney Function Tests - methods</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Technetium Tc 99m Dimercaptosuccinic Acid</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Civan, Caner</creatorcontrib><creatorcontrib>Has Simsek, Duygu</creatorcontrib><creatorcontrib>Kiran, Murat Yilmaz</creatorcontrib><creatorcontrib>Isik, Emine Goknur</creatorcontrib><creatorcontrib>Ozkan, Zeynep Gozde</creatorcontrib><creatorcontrib>Sanli, Yasemin</creatorcontrib><creatorcontrib>Kuyumcu, Serkan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Physica medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Civan, Caner</au><au>Has Simsek, Duygu</au><au>Kiran, Murat Yilmaz</au><au>Isik, Emine Goknur</au><au>Ozkan, Zeynep Gozde</au><au>Sanli, Yasemin</au><au>Kuyumcu, Serkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of 2D planar and 3D volumetric methods for estimation of split renal function by 99m Tc-DMSA scintigraphy</atitle><jtitle>Physica medica</jtitle><addtitle>Phys Med</addtitle><date>2022-03</date><risdate>2022</risdate><volume>95</volume><spage>83</spage><pages>83-</pages><eissn>1724-191X</eissn><abstract>Split renal function (SRF) can be measured by using several methods in
Tc-DMSA scintigraphy. Geometric mean (GM) based methods derived from planar images(2D) have been used for several years, besides; 3D-methods were also reported as an option for assessment of SRF. The purpose of this study to compare 2D and 3D methods for calculation of SRF in pediatric and adult patients.
We evaluated 212 patients, underwent both planar and SPECT
Tc-DMSA scintigraphy.2D-SRFs were calculated by GM without background correction (SRFnobcg), GM with background correction in crescent formation from lower lateral borders (SRFcres), and GM with background correction in circumferential formation, including the whole kidney surroundings (SRFcirc). In 3D settings, SRF was measured with SPECT (SRFspect). Paired t-test was used to compare the mean SRFs of each group. Bland-Altman method was used as an agreement method for each method. Analyses were performed based on left kidney SRFs.
In comparison of 2D and 3D methods, SRFspect was significantly different from SRFnobcg and SRFcres (p=<0.001) but not from SRFcirc (p = 0.155) in all patients. Similar results were found for patients with high creatinine level, SRFcirc and SRFspect were not significantly different (p = 0.317), while significant differences were found between SRFspect and SRFnobcg/SRFcres (p=<0.001).On the other hand, all 2D-methods showed statistical differences (p=<0.001-0.026) from 3D-method in pediatric patients. Bland-Altman-plot demonstrated that SRFcirc underestimated the poor functioning kidneys.
SRFcirc can be used in measurement of SRF in adult patients with normal functioning kidneys in busy clinics. However, SRFspect provides more accurate results and suggested particularly for pediatric patients and poor functioning kidneys.</abstract><cop>Italy</cop><pmid>35134649</pmid><doi>10.1016/j.ejmp.2022.01.010</doi></addata></record> |
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| ispartof | Physica medica, 2022-03, Vol.95, p.83 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Child Humans Kidney - diagnostic imaging Kidney - physiology Kidney Function Tests - methods Radionuclide Imaging Radiopharmaceuticals Technetium Tc 99m Dimercaptosuccinic Acid Tomography, Emission-Computed, Single-Photon - methods |
| title | Comparison of 2D planar and 3D volumetric methods for estimation of split renal function by 99m Tc-DMSA scintigraphy |
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