The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients
This study aimed to explore the relationship between short-term (≤12 months) changes in the estimated glomerular filtration rate (eGFR) and hemoglobin A (HbA ) in patients with type 2 diabetes (T2D). A total of 2,599 patients with T2D were enrolled if they were registered in the Diabetes Sharecare I...
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| Veröffentlicht in: | Frontiers in endocrinology (Lausanne) 2021, Vol.12, p.723720 |
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| creator | An, Lingwang Yu, Qiuzhi Chen, Linhui Tang, Hong Liu, Yanjun Yuan, Qun Ji, Yu Lee, Yaujiunn Lu, Juming |
| description | This study aimed to explore the relationship between short-term (≤12 months) changes in the estimated glomerular filtration rate (eGFR) and hemoglobin A
(HbA
) in patients with type 2 diabetes (T2D).
A total of 2,599 patients with T2D were enrolled if they were registered in the Diabetes Sharecare Information System, were aged 18-75 years, and had 2-3 HbA
and eGFR measurements within the preceding 12 months. The studied patients were categorized into five groups based on eGFR, i.e., the relatively stable (RS), fast decline (FD), modest decline (MD), modest increase (MI), and fast increase (FI) groups.
The median eGFR changes from baseline were -22.14, -6.44, 0.00, 6.32, and 20.00 ml/min per 1.73 m
for patients in the FD, MD, RS, MI, and FI groups, respectively. Up to 1,153 (44.4%) subjects experienced an eGFR decline of ≥3.5 ml/min per 1.73 m
, including 821 (31.6%) FD subjects and 332 (12.8%) MD subjects. A decreased trend was found between the eGFR change and HbA
decrease category, even after multivariable adjustment. In general, an eGFR FD was frequently found in patients who had an HbA
reduction of ≥3.00% and a baseline HbA
≥8.0%; alternatively, such a result was also observed for a urinary albumin-to-creatinine ratio (UACR) of 30.0-300.0 mg/g, regardless of a diabetes duration of |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_35126306</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>35126306</sourcerecordid><originalsourceid>FETCH-pubmed_primary_351263063</originalsourceid><addsrcrecordid>eNqFjs8KgkAYxJcoMspXiO8FAtc1yWP_O4Z4l3X9rBXdlXYlfPuWKOjWXGb4MQwzIjMax9EqZEk4_ske8Y2pA6cooEmymRKPrWkYsyCekTq7I2yN0UJyK7WCHdonogLr-AFFIxWCrgDPpxS4KoFDimUv3l3HL9jqW6MLqWALVIDzbOgQQjhIXqCVAq5uGJU1CzKpeGPQ__icLE_HbH9ZdX3RYpl3D9nyx5B_z7G_hRfuB0Wz</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>An, Lingwang ; Yu, Qiuzhi ; Chen, Linhui ; Tang, Hong ; Liu, Yanjun ; Yuan, Qun ; Ji, Yu ; Lee, Yaujiunn ; Lu, Juming</creator><creatorcontrib>An, Lingwang ; Yu, Qiuzhi ; Chen, Linhui ; Tang, Hong ; Liu, Yanjun ; Yuan, Qun ; Ji, Yu ; Lee, Yaujiunn ; Lu, Juming</creatorcontrib><description>This study aimed to explore the relationship between short-term (≤12 months) changes in the estimated glomerular filtration rate (eGFR) and hemoglobin A
(HbA
) in patients with type 2 diabetes (T2D).
A total of 2,599 patients with T2D were enrolled if they were registered in the Diabetes Sharecare Information System, were aged 18-75 years, and had 2-3 HbA
and eGFR measurements within the preceding 12 months. The studied patients were categorized into five groups based on eGFR, i.e., the relatively stable (RS), fast decline (FD), modest decline (MD), modest increase (MI), and fast increase (FI) groups.
The median eGFR changes from baseline were -22.14, -6.44, 0.00, 6.32, and 20.00 ml/min per 1.73 m
for patients in the FD, MD, RS, MI, and FI groups, respectively. Up to 1,153 (44.4%) subjects experienced an eGFR decline of ≥3.5 ml/min per 1.73 m
, including 821 (31.6%) FD subjects and 332 (12.8%) MD subjects. A decreased trend was found between the eGFR change and HbA
decrease category, even after multivariable adjustment. In general, an eGFR FD was frequently found in patients who had an HbA
reduction of ≥3.00% and a baseline HbA
≥8.0%; alternatively, such a result was also observed for a urinary albumin-to-creatinine ratio (UACR) of 30.0-300.0 mg/g, regardless of a diabetes duration of <10.0 or ≥10.0 years, or in patients who had an HbA
reduction of ≥1.00% accompanied by hyperfiltration.
Some patients with T2D experienced an eGFR FD or MD during the ≤12-month follow-up period. A significant downward trend in eGFR change was demonstrated alongside an HbA
reduction, independent of UACR stage, diabetes duration, and hyperfiltration. Sustained monitoring and cautious interpretation of the HbA
and eGFR changes will be needed in clinical practice.</description><identifier>ISSN: 1664-2392</identifier><identifier>EISSN: 1664-2392</identifier><identifier>PMID: 35126306</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Aged ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - metabolism ; Disease Progression ; Female ; Glomerular Filtration Rate ; Glycated Hemoglobin A - metabolism ; Humans ; Hypoglycemic Agents - therapeutic use ; Male ; Middle Aged</subject><ispartof>Frontiers in endocrinology (Lausanne), 2021, Vol.12, p.723720</ispartof><rights>Copyright © 2022 An, Yu, Chen, Tang, Liu, Yuan, Ji, Lee and Lu.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35126306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Lingwang</creatorcontrib><creatorcontrib>Yu, Qiuzhi</creatorcontrib><creatorcontrib>Chen, Linhui</creatorcontrib><creatorcontrib>Tang, Hong</creatorcontrib><creatorcontrib>Liu, Yanjun</creatorcontrib><creatorcontrib>Yuan, Qun</creatorcontrib><creatorcontrib>Ji, Yu</creatorcontrib><creatorcontrib>Lee, Yaujiunn</creatorcontrib><creatorcontrib>Lu, Juming</creatorcontrib><title>The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients</title><title>Frontiers in endocrinology (Lausanne)</title><addtitle>Front Endocrinol (Lausanne)</addtitle><description>This study aimed to explore the relationship between short-term (≤12 months) changes in the estimated glomerular filtration rate (eGFR) and hemoglobin A
(HbA
) in patients with type 2 diabetes (T2D).
A total of 2,599 patients with T2D were enrolled if they were registered in the Diabetes Sharecare Information System, were aged 18-75 years, and had 2-3 HbA
and eGFR measurements within the preceding 12 months. The studied patients were categorized into five groups based on eGFR, i.e., the relatively stable (RS), fast decline (FD), modest decline (MD), modest increase (MI), and fast increase (FI) groups.
The median eGFR changes from baseline were -22.14, -6.44, 0.00, 6.32, and 20.00 ml/min per 1.73 m
for patients in the FD, MD, RS, MI, and FI groups, respectively. Up to 1,153 (44.4%) subjects experienced an eGFR decline of ≥3.5 ml/min per 1.73 m
, including 821 (31.6%) FD subjects and 332 (12.8%) MD subjects. A decreased trend was found between the eGFR change and HbA
decrease category, even after multivariable adjustment. In general, an eGFR FD was frequently found in patients who had an HbA
reduction of ≥3.00% and a baseline HbA
≥8.0%; alternatively, such a result was also observed for a urinary albumin-to-creatinine ratio (UACR) of 30.0-300.0 mg/g, regardless of a diabetes duration of <10.0 or ≥10.0 years, or in patients who had an HbA
reduction of ≥1.00% accompanied by hyperfiltration.
Some patients with T2D experienced an eGFR FD or MD during the ≤12-month follow-up period. A significant downward trend in eGFR change was demonstrated alongside an HbA
reduction, independent of UACR stage, diabetes duration, and hyperfiltration. Sustained monitoring and cautious interpretation of the HbA
and eGFR changes will be needed in clinical practice.</description><subject>Aged</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1664-2392</issn><issn>1664-2392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs8KgkAYxJcoMspXiO8FAtc1yWP_O4Z4l3X9rBXdlXYlfPuWKOjWXGb4MQwzIjMax9EqZEk4_ske8Y2pA6cooEmymRKPrWkYsyCekTq7I2yN0UJyK7WCHdonogLr-AFFIxWCrgDPpxS4KoFDimUv3l3HL9jqW6MLqWALVIDzbOgQQjhIXqCVAq5uGJU1CzKpeGPQ__icLE_HbH9ZdX3RYpl3D9nyx5B_z7G_hRfuB0Wz</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>An, Lingwang</creator><creator>Yu, Qiuzhi</creator><creator>Chen, Linhui</creator><creator>Tang, Hong</creator><creator>Liu, Yanjun</creator><creator>Yuan, Qun</creator><creator>Ji, Yu</creator><creator>Lee, Yaujiunn</creator><creator>Lu, Juming</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2021</creationdate><title>The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients</title><author>An, Lingwang ; Yu, Qiuzhi ; Chen, Linhui ; Tang, Hong ; Liu, Yanjun ; Yuan, Qun ; Ji, Yu ; Lee, Yaujiunn ; Lu, Juming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_351263063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic Nephropathies - etiology</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Lingwang</creatorcontrib><creatorcontrib>Yu, Qiuzhi</creatorcontrib><creatorcontrib>Chen, Linhui</creatorcontrib><creatorcontrib>Tang, Hong</creatorcontrib><creatorcontrib>Liu, Yanjun</creatorcontrib><creatorcontrib>Yuan, Qun</creatorcontrib><creatorcontrib>Ji, Yu</creatorcontrib><creatorcontrib>Lee, Yaujiunn</creatorcontrib><creatorcontrib>Lu, Juming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Frontiers in endocrinology (Lausanne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Lingwang</au><au>Yu, Qiuzhi</au><au>Chen, Linhui</au><au>Tang, Hong</au><au>Liu, Yanjun</au><au>Yuan, Qun</au><au>Ji, Yu</au><au>Lee, Yaujiunn</au><au>Lu, Juming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients</atitle><jtitle>Frontiers in endocrinology (Lausanne)</jtitle><addtitle>Front Endocrinol (Lausanne)</addtitle><date>2021</date><risdate>2021</risdate><volume>12</volume><spage>723720</spage><pages>723720-</pages><issn>1664-2392</issn><eissn>1664-2392</eissn><abstract>This study aimed to explore the relationship between short-term (≤12 months) changes in the estimated glomerular filtration rate (eGFR) and hemoglobin A
(HbA
) in patients with type 2 diabetes (T2D).
A total of 2,599 patients with T2D were enrolled if they were registered in the Diabetes Sharecare Information System, were aged 18-75 years, and had 2-3 HbA
and eGFR measurements within the preceding 12 months. The studied patients were categorized into five groups based on eGFR, i.e., the relatively stable (RS), fast decline (FD), modest decline (MD), modest increase (MI), and fast increase (FI) groups.
The median eGFR changes from baseline were -22.14, -6.44, 0.00, 6.32, and 20.00 ml/min per 1.73 m
for patients in the FD, MD, RS, MI, and FI groups, respectively. Up to 1,153 (44.4%) subjects experienced an eGFR decline of ≥3.5 ml/min per 1.73 m
, including 821 (31.6%) FD subjects and 332 (12.8%) MD subjects. A decreased trend was found between the eGFR change and HbA
decrease category, even after multivariable adjustment. In general, an eGFR FD was frequently found in patients who had an HbA
reduction of ≥3.00% and a baseline HbA
≥8.0%; alternatively, such a result was also observed for a urinary albumin-to-creatinine ratio (UACR) of 30.0-300.0 mg/g, regardless of a diabetes duration of <10.0 or ≥10.0 years, or in patients who had an HbA
reduction of ≥1.00% accompanied by hyperfiltration.
Some patients with T2D experienced an eGFR FD or MD during the ≤12-month follow-up period. A significant downward trend in eGFR change was demonstrated alongside an HbA
reduction, independent of UACR stage, diabetes duration, and hyperfiltration. Sustained monitoring and cautious interpretation of the HbA
and eGFR changes will be needed in clinical practice.</abstract><cop>Switzerland</cop><pmid>35126306</pmid></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Disease Progression Female Glomerular Filtration Rate Glycated Hemoglobin A - metabolism Humans Hypoglycemic Agents - therapeutic use Male Middle Aged |
| title | The Association Between the Decline of eGFR and a Reduction of Hemoglobin A 1c in Type 2 Diabetic Patients |
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