Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Metabolic reprogramming is a core hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). Here we show that hepatic aldolase B (Aldob) suppresses HCC by directly binding and inhibiting the rate-limiting enzyme in the pentose phosphate pathway, glucose-6-phosphate deh...

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Veröffentlicht in:	Nature cancer 2020-07, Vol.1 (7), p.735
Hauptverfasser:	Li, Min, He, Xuxiao, Guo, Weixing, Yu, Hongming, Zhang, Shicheng, Wang, Ningning, Liu, Guijun, Sa, Rina, Shen, Xia, Jiang, Yabo, Tang, Yufu, Zhuo, Yujuan, Yin, Chunzhao, Tu, Qiaochu, Li, Nan, Nie, Xiaoqun, Li, Yu, Hu, Zhimin, Zhu, Hanwen, Ding, Jianping, Li, Zi, Liu, Te, Zhang, Fan, Zhou, He, Li, Shengxian, Yue, Jiang, Yan, Zheng, Cheng, Shuqun, Tao, Yongzhen, Yin, Huiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - genetics Carcinoma, Hepatocellular - genetics Cell Transformation, Neoplastic Fructose-Bisphosphate Aldolase - genetics Glucosephosphate Dehydrogenase - genetics Humans Liver Neoplasms - genetics Mice Pentose Phosphate Pathway - genetics Tumor Suppressor Protein p53 - genetics
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