Influence of Cell Growth Inhibitors on the Eruption Rate Using the Soft X-ray Photographic Method

I have previously reported that Urethane inhibits tooth eruption. In this paper, Urethane was examined in more detail and compared with the other inhibitors, Mitomycin C, Carboquone,5-Fluorouracil, and Doxorubicin. Urethane inhibited tooth eruption in a dose-dependant manner, although proliferative basal cell growth response was not significantly influenced. There was a tendency towards recovery from the Urethane induced inhibition of the eruption. Mytomycin C, Carboquone,5-Fluorouracil and Doxorubicin had the similar inhibitory effect to Urethane. The dose-dependant responses of Mitomycin C and Urethane were similar. The action of 5-Fluorouracil differed from that of Mitomycin C and Urethane, suggesting a different mode of action. There was no tendency towards recovery from inhibition with 5-Fluorouracil and Mitomycin C. Proliferative basal tissue cell growth response was also strongly depressed, except in the case of Urethane. These actions are considered to be due to the long acting nature and the stronger action on cell growth of these agents.