Molecular Mechanisms of Multimeric Assembly of IgM and IgA
As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into fiv...
Gespeichert in:
| Veröffentlicht in: | Annual review of immunology 2022-04, Vol.40 (1), p.221-247 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 247 |
|---|---|
| container_issue | 1 |
| container_start_page | 221 |
| container_title | Annual review of immunology |
| container_volume | 40 |
| creator | Matsumoto, Marissa L |
| description | As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into five isotypes-IgA, IgD, IgE, IgG, and IgM-each with distinct roles in mediating various aspects of the immune response. Of these isotypes, IgA and IgM are the only ones capable of multimerization, arming them with unique biological functions. Increased valency of polymeric IgA and IgM provides high avidity for binding low-affinity antigens, and their ability to be transported across the mucosal epithelium into secretions by the polymeric immunoglobulin receptor allows them to play critical roles in mucosal immunity. Here we discuss the molecular assembly, structure, and function of these multimeric antibodies. |
| doi_str_mv | 10.1146/annurev-immunol-101320-123742 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_35061510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622281948</sourcerecordid><originalsourceid>FETCH-LOGICAL-a314t-8959facd4565fa8dd2d8b1f7068a623fc5327b30580a19112c27a0d818da325c3</originalsourceid><addsrcrecordid>eNqVkE1LwzAYx4Mobk6_gvQieInmSZo2FTzM4ctgxYueQ5qkWknamazKvr0dnd49_eHh__LwQ-gCyBVAml2rtu2D_cKN933bOQwEGCUYKMtTeoCmwFOOGc3FIZqSnFFMuKATdBLjByGkYCw_RhPGSQYcyBTdlJ2zuncqJKXV76ptoo9JVydl7zaNt6HRyTxG6yu33Z2Xb2WiWjPo_BQd1cpFe7bXGXp9uH9ZPOHV8-NyMV9hxSDdYFHwolbapDzjtRLGUCMqqHOSCZVRVms-fFux4U2ioACgmuaKGAHCKEa5ZjN0OfauQ_fZ27iRvonaOqda2_VR0oxSKqBIxWC9Ha06dDEGW8t1aLwKWwlE7vDJPT65xydHfHLEN-TP91N95a35S__yGgx3o2HXo9zQ1Njv-M-VH3xLhec</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622281948</pqid></control><display><type>article</type><title>Molecular Mechanisms of Multimeric Assembly of IgM and IgA</title><source>Annual Reviews Complete A-Z List</source><source>MEDLINE</source><creator>Matsumoto, Marissa L</creator><creatorcontrib>Matsumoto, Marissa L</creatorcontrib><description>As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into five isotypes-IgA, IgD, IgE, IgG, and IgM-each with distinct roles in mediating various aspects of the immune response. Of these isotypes, IgA and IgM are the only ones capable of multimerization, arming them with unique biological functions. Increased valency of polymeric IgA and IgM provides high avidity for binding low-affinity antigens, and their ability to be transported across the mucosal epithelium into secretions by the polymeric immunoglobulin receptor allows them to play critical roles in mucosal immunity. Here we discuss the molecular assembly, structure, and function of these multimeric antibodies.</description><identifier>ISSN: 0732-0582</identifier><identifier>EISSN: 1545-3278</identifier><identifier>DOI: 10.1146/annurev-immunol-101320-123742</identifier><identifier>PMID: 35061510</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>adaptive immunity ; Animals ; Humans ; Immunity, Mucosal ; Immunoglobulin A ; immunoglobulin J chains ; Immunoglobulin M - chemistry ; Immunoglobulin M - metabolism ; immunoglobulins ; Mammals - metabolism ; Mucous Membrane ; Receptors, Polymeric Immunoglobulin - chemistry ; secretory component ; transcytosis</subject><ispartof>Annual review of immunology, 2022-04, Vol.40 (1), p.221-247</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a314t-8959facd4565fa8dd2d8b1f7068a623fc5327b30580a19112c27a0d818da325c3</citedby><cites>FETCH-LOGICAL-a314t-8959facd4565fa8dd2d8b1f7068a623fc5327b30580a19112c27a0d818da325c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-immunol-101320-123742?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-immunol-101320-123742$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4168,27901,27902,77997,77998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35061510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Marissa L</creatorcontrib><title>Molecular Mechanisms of Multimeric Assembly of IgM and IgA</title><title>Annual review of immunology</title><addtitle>Annu Rev Immunol</addtitle><description>As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into five isotypes-IgA, IgD, IgE, IgG, and IgM-each with distinct roles in mediating various aspects of the immune response. Of these isotypes, IgA and IgM are the only ones capable of multimerization, arming them with unique biological functions. Increased valency of polymeric IgA and IgM provides high avidity for binding low-affinity antigens, and their ability to be transported across the mucosal epithelium into secretions by the polymeric immunoglobulin receptor allows them to play critical roles in mucosal immunity. Here we discuss the molecular assembly, structure, and function of these multimeric antibodies.</description><subject>adaptive immunity</subject><subject>Animals</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A</subject><subject>immunoglobulin J chains</subject><subject>Immunoglobulin M - chemistry</subject><subject>Immunoglobulin M - metabolism</subject><subject>immunoglobulins</subject><subject>Mammals - metabolism</subject><subject>Mucous Membrane</subject><subject>Receptors, Polymeric Immunoglobulin - chemistry</subject><subject>secretory component</subject><subject>transcytosis</subject><issn>0732-0582</issn><issn>1545-3278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1LwzAYx4Mobk6_gvQieInmSZo2FTzM4ctgxYueQ5qkWknamazKvr0dnd49_eHh__LwQ-gCyBVAml2rtu2D_cKN933bOQwEGCUYKMtTeoCmwFOOGc3FIZqSnFFMuKATdBLjByGkYCw_RhPGSQYcyBTdlJ2zuncqJKXV76ptoo9JVydl7zaNt6HRyTxG6yu33Z2Xb2WiWjPo_BQd1cpFe7bXGXp9uH9ZPOHV8-NyMV9hxSDdYFHwolbapDzjtRLGUCMqqHOSCZVRVms-fFux4U2ioACgmuaKGAHCKEa5ZjN0OfauQ_fZ27iRvonaOqda2_VR0oxSKqBIxWC9Ha06dDEGW8t1aLwKWwlE7vDJPT65xydHfHLEN-TP91N95a35S__yGgx3o2HXo9zQ1Njv-M-VH3xLhec</recordid><startdate>20220426</startdate><enddate>20220426</enddate><creator>Matsumoto, Marissa L</creator><general>Annual Reviews</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220426</creationdate><title>Molecular Mechanisms of Multimeric Assembly of IgM and IgA</title><author>Matsumoto, Marissa L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a314t-8959facd4565fa8dd2d8b1f7068a623fc5327b30580a19112c27a0d818da325c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adaptive immunity</topic><topic>Animals</topic><topic>Humans</topic><topic>Immunity, Mucosal</topic><topic>Immunoglobulin A</topic><topic>immunoglobulin J chains</topic><topic>Immunoglobulin M - chemistry</topic><topic>Immunoglobulin M - metabolism</topic><topic>immunoglobulins</topic><topic>Mammals - metabolism</topic><topic>Mucous Membrane</topic><topic>Receptors, Polymeric Immunoglobulin - chemistry</topic><topic>secretory component</topic><topic>transcytosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Marissa L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Marissa L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Mechanisms of Multimeric Assembly of IgM and IgA</atitle><jtitle>Annual review of immunology</jtitle><addtitle>Annu Rev Immunol</addtitle><date>2022-04-26</date><risdate>2022</risdate><volume>40</volume><issue>1</issue><spage>221</spage><epage>247</epage><pages>221-247</pages><issn>0732-0582</issn><eissn>1545-3278</eissn><abstract>As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens through their ability to recognize foreign antigens, aid in neutralization, and facilitate elimination from the host. Mammalian immunoglobulins can be classified into five isotypes-IgA, IgD, IgE, IgG, and IgM-each with distinct roles in mediating various aspects of the immune response. Of these isotypes, IgA and IgM are the only ones capable of multimerization, arming them with unique biological functions. Increased valency of polymeric IgA and IgM provides high avidity for binding low-affinity antigens, and their ability to be transported across the mucosal epithelium into secretions by the polymeric immunoglobulin receptor allows them to play critical roles in mucosal immunity. Here we discuss the molecular assembly, structure, and function of these multimeric antibodies.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>35061510</pmid><doi>10.1146/annurev-immunol-101320-123742</doi><tpages>27</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-0582 |
| ispartof | Annual review of immunology, 2022-04, Vol.40 (1), p.221-247 |
| issn | 0732-0582 1545-3278 |
| language | eng |
| recordid | cdi_pubmed_primary_35061510 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | adaptive immunity Animals Humans Immunity, Mucosal Immunoglobulin A immunoglobulin J chains Immunoglobulin M - chemistry Immunoglobulin M - metabolism immunoglobulins Mammals - metabolism Mucous Membrane Receptors, Polymeric Immunoglobulin - chemistry secretory component transcytosis |
| title | Molecular Mechanisms of Multimeric Assembly of IgM and IgA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T20%3A21%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20Mechanisms%20of%20Multimeric%20Assembly%20of%20IgM%20and%20IgA&rft.jtitle=Annual%20review%20of%20immunology&rft.au=Matsumoto,%20Marissa%20L&rft.date=2022-04-26&rft.volume=40&rft.issue=1&rft.spage=221&rft.epage=247&rft.pages=221-247&rft.issn=0732-0582&rft.eissn=1545-3278&rft_id=info:doi/10.1146/annurev-immunol-101320-123742&rft_dat=%3Cproquest_pubme%3E2622281948%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2622281948&rft_id=info:pmid/35061510&rfr_iscdi=true |