Presynaptic GABA B receptors differentially modulate GABA release from cholecystokinin and parvalbumin interneurons onto CA1 pyramidal neurons: A cell type-specific labeling and activating study
Combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, we compared GABA release from cholecystokinin-expressing (CCK) and parvalbumin-expressing (PV) interneurons onto CA1 pyramidal neurons. Baclofen, a selective GABA receptor agonist, inhibited GABAer...
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| Veröffentlicht in: | Neuroscience letters 2022-02, Vol.772, p.136448 |
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| container_title | Neuroscience letters |
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| creator | Shao, Caifeng Dong, Jiaxue Zhao, Mingwei Liu, Shenhao Wang, Xue Yu, Yang Fang, Lingyan Zhu, Ziying Chen, Qian Xiao, Xu Zhang, Wei-Ning Yang, Kun |
| description | Combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, we compared GABA release from cholecystokinin-expressing (CCK) and parvalbumin-expressing (PV) interneurons onto CA1 pyramidal neurons. Baclofen, a selective GABA
receptor agonist, inhibited GABAergic synaptic transmission greater from CCK terminals, compared to that from PV terminals. The N-type calcium channels on CCK and P/Q-type calcium channels on PV terminals contributed to the GABA
receptor-mediated inhibition, respectively. Our data thus provide direct evidence that GABA
receptors differentially modulate GABA release from CCK and PV interneurons, adding to an increasing list of differences between these two interneuron subtypes in modulating hippocampal pyramidal neurons. |
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receptor agonist, inhibited GABAergic synaptic transmission greater from CCK terminals, compared to that from PV terminals. The N-type calcium channels on CCK and P/Q-type calcium channels on PV terminals contributed to the GABA
receptor-mediated inhibition, respectively. Our data thus provide direct evidence that GABA
receptors differentially modulate GABA release from CCK and PV interneurons, adding to an increasing list of differences between these two interneuron subtypes in modulating hippocampal pyramidal neurons.</description><identifier>EISSN: 1872-7972</identifier><identifier>PMID: 35026332</identifier><language>eng</language><publisher>Ireland</publisher><ispartof>Neuroscience letters, 2022-02, Vol.772, p.136448</ispartof><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35026332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Caifeng</creatorcontrib><creatorcontrib>Dong, Jiaxue</creatorcontrib><creatorcontrib>Zhao, Mingwei</creatorcontrib><creatorcontrib>Liu, Shenhao</creatorcontrib><creatorcontrib>Wang, Xue</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Fang, Lingyan</creatorcontrib><creatorcontrib>Zhu, Ziying</creatorcontrib><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Xiao, Xu</creatorcontrib><creatorcontrib>Zhang, Wei-Ning</creatorcontrib><creatorcontrib>Yang, Kun</creatorcontrib><title>Presynaptic GABA B receptors differentially modulate GABA release from cholecystokinin and parvalbumin interneurons onto CA1 pyramidal neurons: A cell type-specific labeling and activating study</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, we compared GABA release from cholecystokinin-expressing (CCK) and parvalbumin-expressing (PV) interneurons onto CA1 pyramidal neurons. Baclofen, a selective GABA
receptor agonist, inhibited GABAergic synaptic transmission greater from CCK terminals, compared to that from PV terminals. The N-type calcium channels on CCK and P/Q-type calcium channels on PV terminals contributed to the GABA
receptor-mediated inhibition, respectively. Our data thus provide direct evidence that GABA
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receptor agonist, inhibited GABAergic synaptic transmission greater from CCK terminals, compared to that from PV terminals. The N-type calcium channels on CCK and P/Q-type calcium channels on PV terminals contributed to the GABA
receptor-mediated inhibition, respectively. Our data thus provide direct evidence that GABA
receptors differentially modulate GABA release from CCK and PV interneurons, adding to an increasing list of differences between these two interneuron subtypes in modulating hippocampal pyramidal neurons.</abstract><cop>Ireland</cop><pmid>35026332</pmid></addata></record> |
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| title | Presynaptic GABA B receptors differentially modulate GABA release from cholecystokinin and parvalbumin interneurons onto CA1 pyramidal neurons: A cell type-specific labeling and activating study |
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