Gentamicin Inhibits Ca 2+ Channel TRPV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor-Claudin-14 Pathway

Treatment with the aminoglycoside antibiotic gentamicin can be associated with severe adverse effects, including renal Ca wasting. The underlying mechanism is unknown but it has been proposed to involve activation of the Ca -sensing receptor (CaSR) in the thick ascending limb, which would increase e...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2022-03, Vol.33 (3), p.547
Hauptverfasser:	van Megen, Wouter H, Beggs, Megan R, An, Sung-Wan, Ferreira, Patrícia G, Lee, Justin J, Wolf, Matthias T, Alexander, R Todd, Dimke, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Channels - metabolism Carrier Proteins Claudins Gentamicins - pharmacology HEK293 Cells Humans Mice Rabbits Receptors, Calcium-Sensing - genetics TRPV Cation Channels - genetics
Online-Zugang:	Volltext
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