RNA-binding protein p54 nrb /NONO potentiates nuclear EGFR-mediated tumorigenesis of triple-negative breast cancer

Nuclear-localized epidermal growth factor receptor (EGFR) highly correlates with the malignant progression and may be a promising therapeutic target for breast cancer. However, molecular mechanisms of nuclear EGFR in triple-negative breast cancer (TNBC) have not been fully elucidated. Here, we perfo...

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Veröffentlicht in:	Cell death & disease 2022-01, Vol.13 (1), p.42
Hauptverfasser:	Shen, Mengqin, Zhang, Ruixue, Jia, Wenzhi, Zhu, Zongping, Zhao, Li, Huang, Gang, Liu, Jianjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation CREB-Binding Protein - metabolism Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E1A-Associated p300 Protein - metabolism ErbB Receptors - metabolism Female Humans Middle Aged Promoter Regions, Genetic Protein Binding Protein Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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