Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection
Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxi...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1987-12, Vol.84 (23), p.8613-8617 |
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| container_issue | 23 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 84 |
| creator | Cole, Geoffrey A. Cole, Gerald A. Clements, Virginia K. Garcia, Elizabeth P. Ostrand-Rosenberg, Suzanne |
| description | Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection. |
| doi_str_mv | 10.1073/pnas.84.23.8613 |
| format | Article |
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The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.23.8613</identifier><identifier>PMID: 3500477</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Antigens ; Biological and medical sciences ; Cell lines ; Cytotoxicity, Immunologic ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection ; H-2 Antigens - genetics ; H-2 Antigens - immunology ; Histocompatibility antigens class I ; Mice ; Molecules ; Sarcoma ; Sarcoma, Experimental - immunology ; Spleen cells ; T lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Tissue, organ and graft immunology ; Transfection ; Tumor cell line ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1987-12, Vol.84 (23), p.8613-8617</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-769ba8dde90f58eec1c5e2e7b10faf994379a64932aa92668dd56c5f7c3068c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/23.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30515$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30515$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7475891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3500477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cole, Geoffrey A.</creatorcontrib><creatorcontrib>Cole, Gerald A.</creatorcontrib><creatorcontrib>Clements, Virginia K.</creatorcontrib><creatorcontrib>Garcia, Elizabeth P.</creatorcontrib><creatorcontrib>Ostrand-Rosenberg, Suzanne</creatorcontrib><title>Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.</description><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Cell lines</subject><subject>Cytotoxicity, Immunologic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection</subject><subject>H-2 Antigens - genetics</subject><subject>H-2 Antigens - immunology</subject><subject>Histocompatibility antigens class I</subject><subject>Mice</subject><subject>Molecules</subject><subject>Sarcoma</subject><subject>Sarcoma, Experimental - immunology</subject><subject>Spleen cells</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tissue, organ and graft immunology</subject><subject>Transfection</subject><subject>Tumor cell line</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rVDEUxYModayuBUF5C9HVm-b7Y-FiKKMtFApS1yGTSWqGTDIm75X635thntN2000u4fzOvYcDwHsE5wgKcrZLps4lnWMylxyRF2CGoEI9pwq-BDMIseglxfQ1eFPrBkKomIQn4IQwCKkQM7BcxJhvXXLBdhc97hZpCO3bLe93xdUacupC7S5THb0PNrg0dD6X7mbctven2zg7NOYteOVNrO7dNE_Br-_Lm_OL_ur6x-X54qq3Lc_QC65WRq7XTkHPpHMWWeawEysEvfFKUSKUadEJNkZhzhvKuGVeWAK5tJScgm-HvbtxtXVr2-IUE_WuhK0pf3U2QT9VUvitb_OdxkoxxZr_y-Qv-c_o6qC3oVoXo0kuj1ULIZmgnDfw7ADakmstzh9vIKj3xet98VpSjYneF98cHx9HO_JT003_POmmWhN9McmGesQEFUwq1LCvE7bf_199uKP9GOPg7odGfnqWbMCHA7CpQy4PgSBDjPwD5yOtng</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>Cole, Geoffrey A.</creator><creator>Cole, Gerald A.</creator><creator>Clements, Virginia K.</creator><creator>Garcia, Elizabeth P.</creator><creator>Ostrand-Rosenberg, Suzanne</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19871201</creationdate><title>Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection</title><author>Cole, Geoffrey A. ; Cole, Gerald A. ; Clements, Virginia K. ; Garcia, Elizabeth P. ; Ostrand-Rosenberg, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-769ba8dde90f58eec1c5e2e7b10faf994379a64932aa92668dd56c5f7c3068c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Cell lines</topic><topic>Cytotoxicity, Immunologic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection</topic><topic>H-2 Antigens - genetics</topic><topic>H-2 Antigens - immunology</topic><topic>Histocompatibility antigens class I</topic><topic>Mice</topic><topic>Molecules</topic><topic>Sarcoma</topic><topic>Sarcoma, Experimental - immunology</topic><topic>Spleen cells</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Tissue, organ and graft immunology</topic><topic>Transfection</topic><topic>Tumor cell line</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cole, Geoffrey A.</creatorcontrib><creatorcontrib>Cole, Gerald A.</creatorcontrib><creatorcontrib>Clements, Virginia K.</creatorcontrib><creatorcontrib>Garcia, Elizabeth P.</creatorcontrib><creatorcontrib>Ostrand-Rosenberg, Suzanne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cole, Geoffrey A.</au><au>Cole, Gerald A.</au><au>Clements, Virginia K.</au><au>Garcia, Elizabeth P.</au><au>Ostrand-Rosenberg, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>84</volume><issue>23</issue><spage>8613</spage><epage>8617</epage><pages>8613-8617</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3500477</pmid><doi>10.1073/pnas.84.23.8613</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1987-12, Vol.84 (23), p.8613-8617 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Antigens Biological and medical sciences Cell lines Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection H-2 Antigens - genetics H-2 Antigens - immunology Histocompatibility antigens class I Mice Molecules Sarcoma Sarcoma, Experimental - immunology Spleen cells T lymphocytes T-Lymphocytes, Cytotoxic - immunology Tissue, organ and graft immunology Transfection Tumor cell line Tumor Cells, Cultured Tumors |
| title | Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection |
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