Altered glucocorticoid binding and action in response to epidermal growth factor in HBL100 cells

Incubation of adherent human breast epithelial HBL100 cells with epidermal growth factor (EGF) decreased [3H]dexamethasone binding by 35% with no effect on affinity. Maximal inhibition was obtained at 3 nM EGF and the 50% effective dose was 0.2 nM EGF. Decreased dexamethasone binding induced by 3 nM...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-11, Vol.47 (22), p.5888-5893
Hauptverfasser:	RAO, K. V. S, WILLIAMS, R. E, FOX, C. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Cell Line Cell receptors Cell structures and functions Concanavalin A - pharmacology Cytosol - metabolism Dexamethasone - metabolism Dexamethasone - pharmacology Epidermal Growth Factor - pharmacology Epithelium - metabolism Female Fundamental and applied biological sciences. Psychology Humans Kinetics Molecular and cellular biology Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism Tetradecanoylphorbol Acetate - pharmacology
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