Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system

PSENEN/PEN2 is the smallest subunit of the γ-secretase complex, an intramembrane protease that cleaves proteins within their transmembrane domains. Mutations in components of the γ-secretase underlie familial Alzheimer disease. In addition to its proteolytic activity, supplementary, γ-secretase inde...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Autophagy 2022-09, Vol.18 (9), p.2068-2085
Hauptverfasser:	Klein, Marcel, Kaleem, Abuzar, Oetjen, Sandra, Wünkhaus, Daniela, Binkle, Lars, Schilling, Sandra, Gjorgjieva, Milena, Scholz, Ralf, Gruber-Schoffnegger, Doris, Storch, Stephan, Kins, Stefan, Drewes, Gerard, Hoffmeister-Ullerich, Sabine, Kuhl, Dietmar, Hermey, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease cln3 disease knockout cells neuronal ceroid lipofuscinosis Research Paper transcription factor eb γ-secretase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!