K Ca 1.1 K + Channel Inhibition Overcomes Resistance to Antiandrogens and Doxorubicin in a Human Prostate Cancer LNCaP Spheroid Model

Several types of K channels play crucial roles in tumorigenicity, stemness, invasiveness, and drug resistance in cancer. Spheroid formation of human prostate cancer (PC) LNCaP cells with ultra-low attachment surface cultureware induced the up-regulation of cancer stem cell markers, such as NANOG, an...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.22 (24)
Hauptverfasser:	Ohya, Susumu, Kajikuri, Junko, Endo, Kyoko, Kito, Hiroaki, Matsui, Miki
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Antineoplastic Agents - therapeutic use Cell Line, Tumor Doxorubicin - therapeutic use Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Humans Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - antagonists & inhibitors Male Multidrug Resistance-Associated Proteins Neoplastic Stem Cells Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - physiopathology Receptors, Androgen - genetics Spheroids, Cellular
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