Trident cold atmospheric plasma blocks three cancer survival pathways to overcome therapy resistance

Therapy resistance is responsible for most cancer-related death and is mediated by the unique ability of cancer cells to leverage metabolic conditions, signaling molecules, redox status, and other pathways for their survival. Interestingly, many cancer survival pathways are susceptible to disturbanc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-12, Vol.118 (51), p.1-8
Hauptverfasser:	Guo, Bo, Pomicter, Anthony D., Li, Francis, Bhatt, Sudhir, Chen, Chen, Li, Wen, Qi, Miao, Huang, Chen, Deininger, Michael W., Kong, Michael G., Chen, Hai-Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Apoptosis Atmospheric models Biological Sciences Breast cancer Cancer Carcinogenesis CD34 antigen Cell death Cell Line, Tumor Chronic myeloid leukemia Deregulation Gas discharges Glycolysis Hematopoietic stem cells Humans Hypoxia-inducible factor 1a Lactic Acid - metabolism Lethality Leukemia Leukemia, Experimental - mortality Leukemia, Experimental - therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Melanoma Mice Mutation Myeloid leukemia Oxidation-Reduction Physical Sciences Plasma Gases - therapeutic use Progenitor cells Reactive oxygen species Signal transduction Signaling Stem cell transplantation Stem cells Survival Therapy TOR protein Transplantation Tumors
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