ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic factor independent of treatment modality. To survive hypoxia, cells activate macroautophagy/autophagy. Paradoxically, i...

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Veröffentlicht in:	Autophagy 2022-08, Vol.18 (8), p.1898-1914
Hauptverfasser:	Keulers, Tom G., Koch, Alexander, van Gisbergen, Marike W., Barbeau, Lydie M.O., Zonneveld, Marijke I., de Jong, Monique C., Savelkouls, Kim G.M., Wanders, Roel G., Bussink, Johan, Melotte, Veerle, Rouschop, Kasper M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy cancer glucose head and neck cancer hypoxia prognosis radiotherapy glutamine Research Paper
Online-Zugang:	Volltext
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