Computational prediction and validation of specific EmbR binding site on PknH

Tuberculosis drug resistance continues to threaten global health but the underline molecular mechanisms are not clear. Ethambutol (EMB), one of the well-known first - line drugs in tuberculosis treatment is, unfortunately, not free from drug resistance problems. Genomic studies have shown that some...

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Veröffentlicht in:	Synthetic and systems biotechnology 2021-12, Vol.6 (4), p.429-436
Hauptverfasser:	Na, Insung, Dai, Huanqin, Li, Hantian, Gupta, Anvita, Kreda, David, Zhang, Powell, Chen, Xiangyin, Zhang, Lixin, Alterovitz, Gil
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding site prediction Disorder-to-order transition Drug resistance Molecular simulation Protein intrinsic disorder
Online-Zugang:	Volltext
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