Evaluation of a 5-HT 2B receptor agonist in a murine model of amyotrophic lateral sclerosis

Degeneration of brainstem serotonin neurons has been demonstrated in ALS patients and mouse models and was found responsible for the development of spasticity. Consistent with involvement of central serotonin pathways, 5-HT receptor (5-HT R) was upregulated in microglia of ALS mice. Its deletion wor...

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Veröffentlicht in:	Scientific reports 2021-12, Vol.11 (1), p.23582
Hauptverfasser:	Arnoux, Alizée, Ayme-Dietrich, Estelle, Dieterle, Stéphane, Goy, Marc-Antoine, Schann, Stephan, Frauli, Mélanie, Monassier, Laurent, Dupuis, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - metabolism Animals Disease Models, Animal Female Indoles - pharmacology Male Mice Mice, Transgenic Microglia - drug effects Microglia - metabolism Motor Neurons - drug effects Motor Neurons - metabolism Nerve Degeneration - drug therapy Nerve Degeneration - metabolism Receptor, Serotonin, 5-HT2B - metabolism Serotonin - metabolism Serotonin 5-HT2 Receptor Agonists - pharmacology Superoxide Dismutase-1 - metabolism Thiophenes - pharmacology
Online-Zugang:	Volltext
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