Anatase and Rutile TiO 2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway
To evaluate the effects of anatase and rutile TiO nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms. Three-week-old male rats were orally administered anatase TiO NPs and rutile TiO NPs for 28 days. The indicators of rat growth and develop...
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| Veröffentlicht in: | International journal of nanomedicine 2021, Vol.16, p.7233 |
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| container_title | International journal of nanomedicine |
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| creator | Cheng, Wenshu Xu, Xinyue Lang, Yuanyuan Cheng, Zugen Rizwan, Mohammad Tang, Xiaomin Xie, Lixin Liu, Yanling Xu, Hengyi Liu, Yang |
| description | To evaluate the effects of anatase and rutile TiO
nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.
Three-week-old male rats were orally administered anatase TiO
NPs and rutile TiO
NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated. Micro-computed tomography (micro-CT) and immunohistochemistry were used to evaluate the tibia.
No significant differences were observed among growth and development indicators in young rats. Significant differences were found in IGF-1 levels, phosphorus levels, and liver function. Micro-CT revealed osteoporosis in the bones. The micro-CT data supported the same result. Bone immunohistochemistry results showed that the expression of osteoprotegerin (OPG) was decreased and the expression of receptor activator of nuclear factor-κB ligand (RANKL) and cathepsin K (CTSK) was increased.
This study demonstrated that TiO
NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO
NPs damaged the bones more seriously than anatase TiO
NPs. |
| doi_str_mv | 10.2147/IJN.S333632 |
| format | Article |
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nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.
Three-week-old male rats were orally administered anatase TiO
NPs and rutile TiO
NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated. Micro-computed tomography (micro-CT) and immunohistochemistry were used to evaluate the tibia.
No significant differences were observed among growth and development indicators in young rats. Significant differences were found in IGF-1 levels, phosphorus levels, and liver function. Micro-CT revealed osteoporosis in the bones. The micro-CT data supported the same result. Bone immunohistochemistry results showed that the expression of osteoprotegerin (OPG) was decreased and the expression of receptor activator of nuclear factor-κB ligand (RANKL) and cathepsin K (CTSK) was increased.
This study demonstrated that TiO
NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO
NPs damaged the bones more seriously than anatase TiO
NPs.</description><identifier>EISSN: 1178-2013</identifier><identifier>DOI: 10.2147/IJN.S333632</identifier><identifier>PMID: 34737562</identifier><language>eng</language><publisher>New Zealand</publisher><subject>Animals ; Insulin-Like Growth Factor I ; Male ; Nanoparticles ; RANK Ligand ; Rats ; Signal Transduction ; Titanium ; X-Ray Microtomography</subject><ispartof>International journal of nanomedicine, 2021, Vol.16, p.7233</ispartof><rights>2021 Cheng et al.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1755-3010 ; 0000-0003-0457-9665</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34737562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Wenshu</creatorcontrib><creatorcontrib>Xu, Xinyue</creatorcontrib><creatorcontrib>Lang, Yuanyuan</creatorcontrib><creatorcontrib>Cheng, Zugen</creatorcontrib><creatorcontrib>Rizwan, Mohammad</creatorcontrib><creatorcontrib>Tang, Xiaomin</creatorcontrib><creatorcontrib>Xie, Lixin</creatorcontrib><creatorcontrib>Liu, Yanling</creatorcontrib><creatorcontrib>Xu, Hengyi</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><title>Anatase and Rutile TiO 2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway</title><title>International journal of nanomedicine</title><addtitle>Int J Nanomedicine</addtitle><description>To evaluate the effects of anatase and rutile TiO
nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.
Three-week-old male rats were orally administered anatase TiO
NPs and rutile TiO
NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated. Micro-computed tomography (micro-CT) and immunohistochemistry were used to evaluate the tibia.
No significant differences were observed among growth and development indicators in young rats. Significant differences were found in IGF-1 levels, phosphorus levels, and liver function. Micro-CT revealed osteoporosis in the bones. The micro-CT data supported the same result. Bone immunohistochemistry results showed that the expression of osteoprotegerin (OPG) was decreased and the expression of receptor activator of nuclear factor-κB ligand (RANKL) and cathepsin K (CTSK) was increased.
This study demonstrated that TiO
NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO
NPs damaged the bones more seriously than anatase TiO
NPs.</description><subject>Animals</subject><subject>Insulin-Like Growth Factor I</subject><subject>Male</subject><subject>Nanoparticles</subject><subject>RANK Ligand</subject><subject>Rats</subject><subject>Signal Transduction</subject><subject>Titanium</subject><subject>X-Ray Microtomography</subject><issn>1178-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFzjFPwkAUwPGLiRFQJ3fyvkCxdwc9GBUoYhQNsDiRJ30tz1yvTe-K4dvrILPTf_kNfyHuZDxQcmjul8-rwUZrnWh1IbpSmnGkYqk7ouf9VxyPzDiZXImOHhptRonqivDgMKAnQJfBug1sCbb8BgpW6Koam8B7Sx5eCDOY5zntAx8JHitHMMMSCwJ28FG1roA1BnitMrJwZIRwIFgu0kjChguHln_FO4bDN55uxGWO1tPtX69FP51vp09R3X6WlO3qhktsTrvzpv4X_ACzBEsi</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Cheng, Wenshu</creator><creator>Xu, Xinyue</creator><creator>Lang, Yuanyuan</creator><creator>Cheng, Zugen</creator><creator>Rizwan, Mohammad</creator><creator>Tang, Xiaomin</creator><creator>Xie, Lixin</creator><creator>Liu, Yanling</creator><creator>Xu, Hengyi</creator><creator>Liu, Yang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-1755-3010</orcidid><orcidid>https://orcid.org/0000-0003-0457-9665</orcidid></search><sort><creationdate>2021</creationdate><title>Anatase and Rutile TiO 2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway</title><author>Cheng, Wenshu ; Xu, Xinyue ; Lang, Yuanyuan ; Cheng, Zugen ; Rizwan, Mohammad ; Tang, Xiaomin ; Xie, Lixin ; Liu, Yanling ; Xu, Hengyi ; Liu, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_347375623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Insulin-Like Growth Factor I</topic><topic>Male</topic><topic>Nanoparticles</topic><topic>RANK Ligand</topic><topic>Rats</topic><topic>Signal Transduction</topic><topic>Titanium</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Wenshu</creatorcontrib><creatorcontrib>Xu, Xinyue</creatorcontrib><creatorcontrib>Lang, Yuanyuan</creatorcontrib><creatorcontrib>Cheng, Zugen</creatorcontrib><creatorcontrib>Rizwan, Mohammad</creatorcontrib><creatorcontrib>Tang, Xiaomin</creatorcontrib><creatorcontrib>Xie, Lixin</creatorcontrib><creatorcontrib>Liu, Yanling</creatorcontrib><creatorcontrib>Xu, Hengyi</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>International journal of nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Wenshu</au><au>Xu, Xinyue</au><au>Lang, Yuanyuan</au><au>Cheng, Zugen</au><au>Rizwan, Mohammad</au><au>Tang, Xiaomin</au><au>Xie, Lixin</au><au>Liu, Yanling</au><au>Xu, Hengyi</au><au>Liu, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anatase and Rutile TiO 2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway</atitle><jtitle>International journal of nanomedicine</jtitle><addtitle>Int J Nanomedicine</addtitle><date>2021</date><risdate>2021</risdate><volume>16</volume><spage>7233</spage><pages>7233-</pages><eissn>1178-2013</eissn><abstract>To evaluate the effects of anatase and rutile TiO
nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.
Three-week-old male rats were orally administered anatase TiO
NPs and rutile TiO
NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated. Micro-computed tomography (micro-CT) and immunohistochemistry were used to evaluate the tibia.
No significant differences were observed among growth and development indicators in young rats. Significant differences were found in IGF-1 levels, phosphorus levels, and liver function. Micro-CT revealed osteoporosis in the bones. The micro-CT data supported the same result. Bone immunohistochemistry results showed that the expression of osteoprotegerin (OPG) was decreased and the expression of receptor activator of nuclear factor-κB ligand (RANKL) and cathepsin K (CTSK) was increased.
This study demonstrated that TiO
NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO
NPs damaged the bones more seriously than anatase TiO
NPs.</abstract><cop>New Zealand</cop><pmid>34737562</pmid><doi>10.2147/IJN.S333632</doi><orcidid>https://orcid.org/0000-0002-1755-3010</orcidid><orcidid>https://orcid.org/0000-0003-0457-9665</orcidid></addata></record> |
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| identifier | EISSN: 1178-2013 |
| ispartof | International journal of nanomedicine, 2021, Vol.16, p.7233 |
| issn | 1178-2013 |
| language | eng |
| recordid | cdi_pubmed_primary_34737562 |
| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Animals Insulin-Like Growth Factor I Male Nanoparticles RANK Ligand Rats Signal Transduction Titanium X-Ray Microtomography |
| title | Anatase and Rutile TiO 2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway |
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