Phase I and clinical pharmacological study of 4-demethoxydaunorubicin (Idarubicin) in children with advanced cancer

We conducted a phase I and pharmacokinetic study of i.v. idarubicin, a new anthracycline analogue, in 42 evaluable children 1-19 years old. Twenty-seven had leukemia and 15 had various solid tumors. The drug was administered in escalating doses of 10 to 40 mg/m2/course in 3 equal fractions over 3 co...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-06, Vol.47 (11), p.2990-2995
Hauptverfasser:	TAN, C. T. C, HANCOCK, C, NIEDZWIECKI, D, STEVENS, Y.-W, STEINHERZ, P, BACHA, D. M, STEINHERZ, L, LUKS, E, WINICK, N, MEYERS, P, MONDORA, A, DANTIS, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Agents Biological and medical sciences Chemotherapy Child Child, Preschool Daunorubicin - analogs & derivatives Daunorubicin - metabolism Daunorubicin - therapeutic use Dose-Response Relationship, Drug Drug Evaluation Humans Idarubicin Infant Leukemia - blood Leukemia - drug therapy Medical sciences Metabolic Clearance Rate Neoplasms - blood Neoplasms - drug therapy Pharmacology. Drug treatments
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