A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Autoimmune diseases such as rheumatoid arthritis are caused by immune system recognition of self-proteins and subsequent production of effector T cells that recognize and attack healthy tissue. Therapies for these diseases typically utilize broad immune suppression, which can be effective, but which...

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Veröffentlicht in:	Pharmaceutics 2021-10, Vol.13 (10), p.1669
Hauptverfasser:	Goldberg, Shalom D, Felix, Nathan, McCauley, Michael, Eberwine, Ryan, Casta, Lou, Haskell, Kathleen, Lin, Tricia, Palovick, Elizabeth, Klein, Donna, Getts, Lori, Getts, Robert, Zhou, Mimi, Bansal-Pakala, Pratima, Dudkin, Vadim
Format:	Artikel
Sprache:	eng
Schlagworte:	3DNA Amino acids Antigens autoimmune disease bioconjugates Chromatography Cytotoxicity Disease Immune system Immunology Lymphocytes Mutation Nanomaterials peptide-MHC complexes Peptides Plasmids Proteins T cell receptors
Online-Zugang:	Volltext
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