Local neuromuscular characteristics associated with patellofemoral pain: A systematic review and meta-analysis

Local neuromuscular deficits have been reported in people with patellofemoral pain. We synthesised the neuromuscular characteristics associated with patellofemoral pain to help identify interventional targets and potential mechanisms. Five databases were searched for local neuromuscular characteristics in case-control studies. Electromyography, flexibility, muscle performance and cross-sectional area data were derived from functional or isolated task investigations and synthesised accordingly. An evidence gap map was constructed. Sixty-seven studies were included. In functional tasks, electromyographic investigations showed moderate evidence of small effect for vastus medialis onset-delays relative to vastus lateralis (0.44 [0.03, 0.85]) during stepping/stair negotiation tasks, and higher biceps femoris mean excitation amplitudes (0.55 [0.06, 1.04]) in single-leg triple-hop test. In isolated tasks, we found moderate evidence of medium effect for lower Hoffman-reflex amplitude of vastus medialis (−1.12 [−1.56, −0.67]). Muscle performance investigations showed; strong evidence with medium and small effects for lower extensors concentric (−0.61 [−0.81, −0.40]) and eccentric (−0.56 [−0.79, −0.33]) strength, and moderate evidence of medium effect of lower isometric (−0.64 [−0.87, −0.41]) strength, moderate evidence with small effect for rate of force development to 30% (−0.55[−0.89, −0.21]), 60% (−0.57[−0.90, −0.25]) and medium effect to 90% (−0.76[−1.43, −0.10]) of maximum voluntary contraction, and small effect for lower flexors concentric strength (−0.46 [−0.74, −0.19]) and extensors total work (−0.48 [−0.90, −0.07]). Flexibility investigations showed tighter hamstrings (−0.57 [−0.99, −0.14]). Differences within quadriceps and hamstrings motor-control, hamstrings tightness, and quadriceps and hamstrings weakness are associated with patellofemoral pain, and can be used to guide investigations of treatment effects. •Ten local neuromuscular deficits have been shown to be associated with patellofemoral pain.•The specific methodologies required to detect these deficits have been identified.•Quadriceps muscle deficits have been robustly established.•Gaps in other local muscle deficits have been presented to inform future research.