Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM 2.5

Fine particulate matter (PM ) exposure can cause the injury of vascular endothelial cells by inflammatory response. CD40 works in inflammation of endothelial cells and it may be regulated by the miRNAs. This study aimed to clarify the role and mechanism of CD40 and miR-145-5p in PM -induced injury o...

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Veröffentlicht in:	Toxicology (Amsterdam) 2021-12, Vol.464, p.152993
Hauptverfasser:	Zhang, Xueting, Qi, Wen, Shi, Yanbin, Li, Xu, Yin, Jianli, Huo, Chuanyi, Zhang, Ruxuan, Zhao, Weisen, Ye, Jiaming, Zhou, Liting, Ye, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects CD40 Ligand - genetics Cell Survival - drug effects Down-Regulation - drug effects Gene Silencing Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - pathology Humans Inflammation - chemically induced Inflammation - pathology MicroRNAs - genetics Particulate Matter - toxicity RNA, Messenger - metabolism RNA, Small Interfering - administration & dosage
Online-Zugang:	Volltext
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