Determination of in vivo virtue of dermal targeted combinatorial lipid nanocolloidal based formulation of 5-fluorouracil and resveratrol against skin cancer

[Display omitted] •Concentration of gelling agent has been optimized for the combinatorial linogel.•Excellent occlusiveness of linogel was due to lipidic behavior of linogel.•Linogel was found dermally safe due to drug entrapment inside the lipid-nanosystem.•Combinatorial linogel exhibited improved...

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Veröffentlicht in:International journal of pharmaceutics 2021-12, Vol.610, p.121179-121179, Article 121179
Hauptverfasser: Iqubal, Mohammad Kashif, Iqubal, Ashif, Anjum, Hasib, Gupta, Madan Mohan, Ali, Javed, Baboota, Sanjula
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Sprache:eng
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Zusammenfassung:[Display omitted] •Concentration of gelling agent has been optimized for the combinatorial linogel.•Excellent occlusiveness of linogel was due to lipidic behavior of linogel.•Linogel was found dermally safe due to drug entrapment inside the lipid-nanosystem.•Combinatorial linogel exhibited improved apoptosis and anti-proliferative effects.•Stability study revealed the durability of the linogel. The current study has been designed to appraise the efficacy of developed combinatorial lipid-nanosystem-based gel (linogel) of 5-fluorouracil and resveratrol for skin cancer treatment. Initially, linogel was prepared and characterized for different parameters, namely pH, texture, drug content uniformity, occlusiveness, etc. Then in vivo efficacy studies (tumor number, area, and volume, histopathology, ultrastructural and immunohistochemical analysis) of linogel were determined over-developed skin tumors. Developed linogel possessed significantly (p 
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2021.121179