Quantitation of plasma metanephrines using isotope dilution liquid chromatography tandem mass spectrometry (ID-LC/MS/MS): a candidate reference measurement procedure and its application to evaluating routine ID-LC/MS/MS methods

Accurate measurement of plasma metanephrines (MNs) including metanephrine (MN) and normetanephrine (NMN) is crucial for the screening and diagnosis in pheochromocytomas and paragangliomas (PPGLs). Although the number of laboratories using liquid chromatography tandem mass spectrometry (LC–MS/MS) met...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2021-12, Vol.413 (30), p.7509-7520
Hauptverfasser:	Liu, Zhenni, Liu, Qingxiang, Deng, Yuhang, Zhao, Haijian, Zeng, Jie, Zhang, Tianjiao, Zhang, Jiangtao, Wang, Jing, Zhou, Weiyan, Zhang, Chuanbao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Biochemical Research Methods Biochemistry Biochemistry & Molecular Biology Blood plasma Calibration Characterization and Evaluation of Materials Chemical precipitation Chemistry Chemistry and Materials Science Chemistry, Analytical Chromatography Chromatography, Liquid - methods Coefficient of variation Dilution Epinephrine Evaluation Food Science Humans Identification and classification Indicator Dilution Techniques Ion exchange Laboratories Laboratory Medicine Life Sciences & Biomedicine Limit of Detection Liquid chromatography Mass spectrometry Mass spectroscopy Materials traceability Mathematical analysis Measurement Metanephrine - blood Metanephrine - standards Methods Monitoring/Environmental Analysis Neuroendocrine tumors Paraganglioma Physical Sciences Plasma Quantitation Reference materials Reference Standards Reproducibility of Results Research Paper Science & Technology Scientific imaging Solid phases Spectroscopy Standardization Tandem Mass Spectrometry
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