PaO 2 /FiO 2 ratio forecasts COVID-19 patients' outcome regardless of age: a cross-sectional, monocentric study
We studied the predictive value of the PaO /FiO ratio for classifying COVID-19-positive patients who will develop severe clinical outcomes. One hundred fifty patients were recruited and categorized into two distinct populations ("A" and "B"), according to the indications given by...
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| Veröffentlicht in: | Internal and emergency medicine 2022-04, Vol.17 (3), p.665 |
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| creator | Sinatti, Gaia Santini, Silvano Junior Tarantino, Giovanni Picchi, Giovanna Cosimini, Benedetta Ranfone, Francesca Casano, Nicolò Zingaropoli, Maria Antonella Iapadre, Nerio Bianconi, Simone Armiento, Antonietta Carducci, Paolo Ciardi, Maria Rosa Mastroianni, Claudio Maria Grimaldi, Alessandro Balsano, Clara |
| description | We studied the predictive value of the PaO
/FiO
ratio for classifying COVID-19-positive patients who will develop severe clinical outcomes. One hundred fifty patients were recruited and categorized into two distinct populations ("A" and "B"), according to the indications given by the World Health Organization. Patients belonging the population "A" presented with mild disease not requiring oxygen support, whereas population "B" presented with a severe disease needing oxygen support. The AUC curve of PaO
/FiO
in the discovery cohort was 0.838 (95% CI 0.771-0.908). The optimal cut-off value for distinguishing population "A" from the "B" one, calculated by Youden's index, with sensitivity of 71.79% and specificity 85.25%, LR+4.866, LR-0.339, was |
| format | Article |
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/FiO
ratio for classifying COVID-19-positive patients who will develop severe clinical outcomes. One hundred fifty patients were recruited and categorized into two distinct populations ("A" and "B"), according to the indications given by the World Health Organization. Patients belonging the population "A" presented with mild disease not requiring oxygen support, whereas population "B" presented with a severe disease needing oxygen support. The AUC curve of PaO
/FiO
in the discovery cohort was 0.838 (95% CI 0.771-0.908). The optimal cut-off value for distinguishing population "A" from the "B" one, calculated by Youden's index, with sensitivity of 71.79% and specificity 85.25%, LR+4.866, LR-0.339, was < 274 mmHg. The AUC in the validation cohort of 170 patients overlapped the previous one, i.e., 0.826 (95% CI 0.760-0.891). PaO
/FiO
ratio < 274 mmHg was a good predictive index test to forecast the development of a severe respiratory failure in SARS-CoV-2-infected patients. Moreover, our work highlights that PaO
/FiO
ratio, compared to inflammatory scores (hs-CRP, NLR, PLR and LDH) indicated to be useful in clinical managements, results to be the most reliable parameter to identify patients who require closer respiratory monitoring and more aggressive supportive therapies. Clinical trial registration: Prognostic Score in COVID-19, prot. NCT04780373 https://clinicaltrials.gov/ct2/show/NCT04780373 (retrospectively registered).</description><identifier>EISSN: 1970-9366</identifier><identifier>PMID: 34637082</identifier><language>eng</language><publisher>Italy</publisher><subject>COVID-19 ; Cross-Sectional Studies ; Humans ; Oxygen ; Respiratory Insufficiency - therapy ; SARS-CoV-2</subject><ispartof>Internal and emergency medicine, 2022-04, Vol.17 (3), p.665</ispartof><rights>2021. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9615-7031</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34637082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sinatti, Gaia</creatorcontrib><creatorcontrib>Santini, Silvano Junior</creatorcontrib><creatorcontrib>Tarantino, Giovanni</creatorcontrib><creatorcontrib>Picchi, Giovanna</creatorcontrib><creatorcontrib>Cosimini, Benedetta</creatorcontrib><creatorcontrib>Ranfone, Francesca</creatorcontrib><creatorcontrib>Casano, Nicolò</creatorcontrib><creatorcontrib>Zingaropoli, Maria Antonella</creatorcontrib><creatorcontrib>Iapadre, Nerio</creatorcontrib><creatorcontrib>Bianconi, Simone</creatorcontrib><creatorcontrib>Armiento, Antonietta</creatorcontrib><creatorcontrib>Carducci, Paolo</creatorcontrib><creatorcontrib>Ciardi, Maria Rosa</creatorcontrib><creatorcontrib>Mastroianni, Claudio Maria</creatorcontrib><creatorcontrib>Grimaldi, Alessandro</creatorcontrib><creatorcontrib>Balsano, Clara</creatorcontrib><title>PaO 2 /FiO 2 ratio forecasts COVID-19 patients' outcome regardless of age: a cross-sectional, monocentric study</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><description>We studied the predictive value of the PaO
/FiO
ratio for classifying COVID-19-positive patients who will develop severe clinical outcomes. One hundred fifty patients were recruited and categorized into two distinct populations ("A" and "B"), according to the indications given by the World Health Organization. Patients belonging the population "A" presented with mild disease not requiring oxygen support, whereas population "B" presented with a severe disease needing oxygen support. The AUC curve of PaO
/FiO
in the discovery cohort was 0.838 (95% CI 0.771-0.908). The optimal cut-off value for distinguishing population "A" from the "B" one, calculated by Youden's index, with sensitivity of 71.79% and specificity 85.25%, LR+4.866, LR-0.339, was < 274 mmHg. The AUC in the validation cohort of 170 patients overlapped the previous one, i.e., 0.826 (95% CI 0.760-0.891). PaO
/FiO
ratio < 274 mmHg was a good predictive index test to forecast the development of a severe respiratory failure in SARS-CoV-2-infected patients. Moreover, our work highlights that PaO
/FiO
ratio, compared to inflammatory scores (hs-CRP, NLR, PLR and LDH) indicated to be useful in clinical managements, results to be the most reliable parameter to identify patients who require closer respiratory monitoring and more aggressive supportive therapies. Clinical trial registration: Prognostic Score in COVID-19, prot. NCT04780373 https://clinicaltrials.gov/ct2/show/NCT04780373 (retrospectively registered).</description><subject>COVID-19</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Oxygen</subject><subject>Respiratory Insufficiency - therapy</subject><subject>SARS-CoV-2</subject><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjrsKwkAQRRdBfP-CTGdjMA9NjK0PtNJCbGXcTEIkyYSdTeHfG0Frq1Pcey63owZeHLlOHIRhXw1Fnq67WoVe1FP9YBkGkbv2B4oveAYfFof8A4M2Z0jZkEaxAtvz7bRzvBjqNqDKygy4sZpLAkMZmqQgEeAUMKMNIGjDIo6QbmcqLOZQcsW6FU2uQWyTvMaqm2IhNPlypKaH_XV7dOrmUVJyr01eonndfw-Dv4U37LlFjA</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Sinatti, Gaia</creator><creator>Santini, Silvano Junior</creator><creator>Tarantino, Giovanni</creator><creator>Picchi, Giovanna</creator><creator>Cosimini, Benedetta</creator><creator>Ranfone, Francesca</creator><creator>Casano, Nicolò</creator><creator>Zingaropoli, Maria Antonella</creator><creator>Iapadre, Nerio</creator><creator>Bianconi, Simone</creator><creator>Armiento, Antonietta</creator><creator>Carducci, Paolo</creator><creator>Ciardi, Maria Rosa</creator><creator>Mastroianni, Claudio Maria</creator><creator>Grimaldi, Alessandro</creator><creator>Balsano, Clara</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-9615-7031</orcidid></search><sort><creationdate>202204</creationdate><title>PaO 2 /FiO 2 ratio forecasts COVID-19 patients' outcome regardless of age: a cross-sectional, monocentric study</title><author>Sinatti, Gaia ; Santini, Silvano Junior ; Tarantino, Giovanni ; Picchi, Giovanna ; Cosimini, Benedetta ; Ranfone, Francesca ; Casano, Nicolò ; Zingaropoli, Maria Antonella ; Iapadre, Nerio ; Bianconi, Simone ; Armiento, Antonietta ; Carducci, Paolo ; Ciardi, Maria Rosa ; Mastroianni, Claudio Maria ; Grimaldi, Alessandro ; Balsano, Clara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_346370823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>COVID-19</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Oxygen</topic><topic>Respiratory Insufficiency - therapy</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sinatti, Gaia</creatorcontrib><creatorcontrib>Santini, Silvano Junior</creatorcontrib><creatorcontrib>Tarantino, Giovanni</creatorcontrib><creatorcontrib>Picchi, Giovanna</creatorcontrib><creatorcontrib>Cosimini, Benedetta</creatorcontrib><creatorcontrib>Ranfone, Francesca</creatorcontrib><creatorcontrib>Casano, Nicolò</creatorcontrib><creatorcontrib>Zingaropoli, Maria Antonella</creatorcontrib><creatorcontrib>Iapadre, Nerio</creatorcontrib><creatorcontrib>Bianconi, Simone</creatorcontrib><creatorcontrib>Armiento, Antonietta</creatorcontrib><creatorcontrib>Carducci, Paolo</creatorcontrib><creatorcontrib>Ciardi, Maria Rosa</creatorcontrib><creatorcontrib>Mastroianni, Claudio Maria</creatorcontrib><creatorcontrib>Grimaldi, Alessandro</creatorcontrib><creatorcontrib>Balsano, Clara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sinatti, Gaia</au><au>Santini, Silvano Junior</au><au>Tarantino, Giovanni</au><au>Picchi, Giovanna</au><au>Cosimini, Benedetta</au><au>Ranfone, Francesca</au><au>Casano, Nicolò</au><au>Zingaropoli, Maria Antonella</au><au>Iapadre, Nerio</au><au>Bianconi, Simone</au><au>Armiento, Antonietta</au><au>Carducci, Paolo</au><au>Ciardi, Maria Rosa</au><au>Mastroianni, Claudio Maria</au><au>Grimaldi, Alessandro</au><au>Balsano, Clara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PaO 2 /FiO 2 ratio forecasts COVID-19 patients' outcome regardless of age: a cross-sectional, monocentric study</atitle><jtitle>Internal and emergency medicine</jtitle><addtitle>Intern Emerg Med</addtitle><date>2022-04</date><risdate>2022</risdate><volume>17</volume><issue>3</issue><spage>665</spage><pages>665-</pages><eissn>1970-9366</eissn><abstract>We studied the predictive value of the PaO
/FiO
ratio for classifying COVID-19-positive patients who will develop severe clinical outcomes. One hundred fifty patients were recruited and categorized into two distinct populations ("A" and "B"), according to the indications given by the World Health Organization. Patients belonging the population "A" presented with mild disease not requiring oxygen support, whereas population "B" presented with a severe disease needing oxygen support. The AUC curve of PaO
/FiO
in the discovery cohort was 0.838 (95% CI 0.771-0.908). The optimal cut-off value for distinguishing population "A" from the "B" one, calculated by Youden's index, with sensitivity of 71.79% and specificity 85.25%, LR+4.866, LR-0.339, was < 274 mmHg. The AUC in the validation cohort of 170 patients overlapped the previous one, i.e., 0.826 (95% CI 0.760-0.891). PaO
/FiO
ratio < 274 mmHg was a good predictive index test to forecast the development of a severe respiratory failure in SARS-CoV-2-infected patients. Moreover, our work highlights that PaO
/FiO
ratio, compared to inflammatory scores (hs-CRP, NLR, PLR and LDH) indicated to be useful in clinical managements, results to be the most reliable parameter to identify patients who require closer respiratory monitoring and more aggressive supportive therapies. Clinical trial registration: Prognostic Score in COVID-19, prot. NCT04780373 https://clinicaltrials.gov/ct2/show/NCT04780373 (retrospectively registered).</abstract><cop>Italy</cop><pmid>34637082</pmid><orcidid>https://orcid.org/0000-0002-9615-7031</orcidid></addata></record> |
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| identifier | EISSN: 1970-9366 |
| ispartof | Internal and emergency medicine, 2022-04, Vol.17 (3), p.665 |
| issn | 1970-9366 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | COVID-19 Cross-Sectional Studies Humans Oxygen Respiratory Insufficiency - therapy SARS-CoV-2 |
| title | PaO 2 /FiO 2 ratio forecasts COVID-19 patients' outcome regardless of age: a cross-sectional, monocentric study |
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