Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

The family of PIM serine/threonine kinases includes three highly conserved oncogenes, PIM1, PIM2, and PIM3 , which regulate multiple prosurvival pathways and cooperate with other oncogenes such as MYC. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions of PIMs in diffuse larg...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-12, Vol.81 (23), p.6029-6043
Hauptverfasser:	Szydlowski, Maciej, Garbicz, Filip, Jablonska, Ewa, Gorniak, Patryk, Komar, Dorota, Pyrzynska, Beata, Bojarczuk, Kamil, Prochorec-Sobieszek, Monika, Szumera-Cieckiewicz, Anna, Rymkiewicz, Grzegorz, Cybulska, Magdalena, Statkiewicz, Malgorzata, Gajewska, Marta, Mikula, Michal, Golas, Aniela, Domagala, Joanna, Winiarska, Magdalena, Graczyk-Jarzynka, Agnieszka, Bialopiotrowicz, Emilia, Polak, Anna, Barankiewicz, Joanna, Pula, Bartosz, Pawlak, Michal, Nowis, Dominika, Golab, Jakub, Tomirotti, Andrea M., Brzozka, Krzysztof, Pacheco-Blanco, Mariana, Kupcova, Kristyna, Green, Michael R., Havranek, Ondrej, Chapuy, Bjoern, Juszczynski, Przemyslaw
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD20 Antineoplastic Agents, Immunological - pharmacology Apoptosis Cell Proliferation Female Gene Expression Regulation, Neoplastic - drug effects Humans Life Sciences & Biomedicine Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Mice Mice, SCID Oncology Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors Rituximab - pharmacology Science & Technology Tumor Cells, Cultured Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!