Obesity as a Thrombogenic and Cardiovascular Risk Factor in Children

Obesity as a Thrombogenic and Cardiovascular Risk Factor in Children

Background/Aims: Obesity leads to increased risk of thromboembolic events in adults, but few studies have addressed the relationship between obesity and thrombogenic risk during childhood. The aim of this study was to evaluate the prothrombotic state of obese children in comparison with healthy chil...

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Veröffentlicht in:Hormone research in paediatrics 2021, Vol.94 (11-12), p.410-415
Hauptverfasser: Cominato, Louise, Franco, Ruth Rocha, Ybarra, Marina, Frascino, Alexandre Viana, Steinmetz, Leandra, Ferraro, Alexandre Archanjo, Aivazoglou Carneiro, Jorge David, Damiani, Durval
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container_end_page 415
container_issue 11-12
container_start_page 410
container_title Hormone research in paediatrics
container_volume 94
creator Cominato, Louise
Franco, Ruth Rocha
Ybarra, Marina
Frascino, Alexandre Viana
Steinmetz, Leandra
Ferraro, Alexandre Archanjo
Aivazoglou Carneiro, Jorge David
Damiani, Durval
description Background/Aims: Obesity leads to increased risk of thromboembolic events in adults, but few studies have addressed the relationship between obesity and thrombogenic risk during childhood. The aim of this study was to evaluate the prothrombotic state of obese children in comparison with healthy children. Methods: Thrombin generation, fibrinogen, and D-dimer levels, along with metabolic parameters, were measured in 72 prepubertal children, of which 47 were obese and 25 eutrophic. Results: A significant increase in thrombin generation, fibrinogen, and dyslipidemia was found among obese patients. Conclusion: A prothrombotic state develops in childhood obesity during the prepubertal phase.
doi_str_mv 10.1159/000519264
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title Obesity as a Thrombogenic and Cardiovascular Risk Factor in Children
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