Repurposing Colchicine for Heart Disease
Colchicine is one of the most ancient medications still prescribed. It is extracted from the Colchicum autumnale plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 2022-01, Vol.62 (1), p.121-129 |
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| container_title | Annual review of pharmacology and toxicology |
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| creator | Bouabdallaoui, Nadia Tardif, Jean-Claude |
| description | Colchicine is one of the most ancient medications still prescribed. It is extracted from the
Colchicum autumnale
plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in which inflammation is a key component, and it has become first-line therapy for acute and recurrent pericarditis. Two landmark clinical trials have recently shown that colchicine significantly improves cardiovascular outcomes on background statin and antiplatelet therapy in patients with coronary artery disease, supporting its role for the prevention of atherothrombotic events. Favorable results have also emerged in atrial fibrillation. We herein briefly review the most recent data related to the multiple cardiovascular conditions for which colchicine has been successfully repurposed. |
| doi_str_mv | 10.1146/annurev-pharmtox-052120-020445 |
| format | Article |
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Colchicum autumnale
plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in which inflammation is a key component, and it has become first-line therapy for acute and recurrent pericarditis. Two landmark clinical trials have recently shown that colchicine significantly improves cardiovascular outcomes on background statin and antiplatelet therapy in patients with coronary artery disease, supporting its role for the prevention of atherothrombotic events. Favorable results have also emerged in atrial fibrillation. We herein briefly review the most recent data related to the multiple cardiovascular conditions for which colchicine has been successfully repurposed.</description><identifier>ISSN: 0362-1642</identifier><identifier>EISSN: 1545-4304</identifier><identifier>DOI: 10.1146/annurev-pharmtox-052120-020445</identifier><identifier>PMID: 34587458</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>atrial fibrillation ; cardiovascular disease ; colchicine ; coronary artery disease ; inflammation ; secondary prevention</subject><ispartof>Annual review of pharmacology and toxicology, 2022-01, Vol.62 (1), p.121-129</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a387t-44a1b4989efebea87a1c192784ce9621b97b160a3e20238ebb6cff56618180563</citedby><cites>FETCH-LOGICAL-a387t-44a1b4989efebea87a1c192784ce9621b97b160a3e20238ebb6cff56618180563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-pharmtox-052120-020445?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-pharmtox-052120-020445$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4167,27903,27904,78000,78001</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34587458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouabdallaoui, Nadia</creatorcontrib><creatorcontrib>Tardif, Jean-Claude</creatorcontrib><title>Repurposing Colchicine for Heart Disease</title><title>Annual review of pharmacology and toxicology</title><addtitle>Annu Rev Pharmacol Toxicol</addtitle><description>Colchicine is one of the most ancient medications still prescribed. It is extracted from the
Colchicum autumnale
plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in which inflammation is a key component, and it has become first-line therapy for acute and recurrent pericarditis. Two landmark clinical trials have recently shown that colchicine significantly improves cardiovascular outcomes on background statin and antiplatelet therapy in patients with coronary artery disease, supporting its role for the prevention of atherothrombotic events. Favorable results have also emerged in atrial fibrillation. We herein briefly review the most recent data related to the multiple cardiovascular conditions for which colchicine has been successfully repurposed.</description><subject>atrial fibrillation</subject><subject>cardiovascular disease</subject><subject>colchicine</subject><subject>coronary artery disease</subject><subject>inflammation</subject><subject>secondary prevention</subject><issn>0362-1642</issn><issn>1545-4304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqVkE1Lw0AQhhdRbK3-BclJvKzO7Fc2F0FStUJBED0vmzixkTYJu60f_96UtN49DHN532eYh7ELhCtEZa5902wCffJu4cNq3X5z0AIFcBCglD5gY9RKcyVBHbIxSCM4GiVG7CTGDwDIpMJjNpJK27SfMbt8pm4TujbWzXuSt8tyUZd1Q0nVhmRGPqyTaR3JRzplR5VfRjrb7Ql7vb97yWd8_vTwmN_OuZc2XXOlPBYqsxlVVJC3qccSM5FaVVJmBBZZWqABL0mAkJaKwpRVpY1Bixa0kRN2M3DL0MYYqHJdqFc-_DgEt1XgdgrcXoEbFLhBQQ84HwDdpljR2199_3MfyIfAFuSXPaqmr_jfM78iNXPZ</recordid><startdate>20220106</startdate><enddate>20220106</enddate><creator>Bouabdallaoui, Nadia</creator><creator>Tardif, Jean-Claude</creator><general>Annual Reviews</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220106</creationdate><title>Repurposing Colchicine for Heart Disease</title><author>Bouabdallaoui, Nadia ; Tardif, Jean-Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a387t-44a1b4989efebea87a1c192784ce9621b97b160a3e20238ebb6cff56618180563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>atrial fibrillation</topic><topic>cardiovascular disease</topic><topic>colchicine</topic><topic>coronary artery disease</topic><topic>inflammation</topic><topic>secondary prevention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouabdallaoui, Nadia</creatorcontrib><creatorcontrib>Tardif, Jean-Claude</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annual review of pharmacology and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouabdallaoui, Nadia</au><au>Tardif, Jean-Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repurposing Colchicine for Heart Disease</atitle><jtitle>Annual review of pharmacology and toxicology</jtitle><addtitle>Annu Rev Pharmacol Toxicol</addtitle><date>2022-01-06</date><risdate>2022</risdate><volume>62</volume><issue>1</issue><spage>121</spage><epage>129</epage><pages>121-129</pages><issn>0362-1642</issn><eissn>1545-4304</eissn><abstract>Colchicine is one of the most ancient medications still prescribed. It is extracted from the
Colchicum autumnale
plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in which inflammation is a key component, and it has become first-line therapy for acute and recurrent pericarditis. Two landmark clinical trials have recently shown that colchicine significantly improves cardiovascular outcomes on background statin and antiplatelet therapy in patients with coronary artery disease, supporting its role for the prevention of atherothrombotic events. Favorable results have also emerged in atrial fibrillation. We herein briefly review the most recent data related to the multiple cardiovascular conditions for which colchicine has been successfully repurposed.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>34587458</pmid><doi>10.1146/annurev-pharmtox-052120-020445</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-1642 |
| ispartof | Annual review of pharmacology and toxicology, 2022-01, Vol.62 (1), p.121-129 |
| issn | 0362-1642 1545-4304 |
| language | eng |
| recordid | cdi_pubmed_primary_34587458 |
| source | Annual Reviews Complete A-Z List |
| subjects | atrial fibrillation cardiovascular disease colchicine coronary artery disease inflammation secondary prevention |
| title | Repurposing Colchicine for Heart Disease |
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