Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae

Ceftazidime-avibactam (CAZ-AVI) shows promising activity against carbapenem-resistant Klebsiella pneumoniae (CRKP), however, CAZ-AVI resistance have emerged recently. Mutations in KPCs, porins OmpK35 and/or OmpK36, and PBPs are known to contribute to the resistance to CAZ-AVI in CRKP. To identify no...

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Veröffentlicht in:	Emerging microbes & infections 2021-01, Vol.10 (1), p.2042-2051
Hauptverfasser:	Guo, Yingyi, Liu, Ningjing, Lin, Zhiwei, Ba, Xiaoliang, Zhuo, Chuyue, Li, Feifeng, Wang, Jiong, Li, Yitan, Yao, Likang, Liu, Baomo, Xiao, Shunian, Jiang, Ying, Zhuo, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Azabicyclo Compounds - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenem-Resistant Enterobacteriaceae - metabolism Ceftazidime - pharmacology Ceftazidime-avibactam Drug Combinations Drug Resistance, Bacterial expression level of bla expression level of blaKPC Humans Klebsiella Infections - microbiology KPC LamB Original PBP3 Porins - genetics Porins - metabolism
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