BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A 2 versatility

Phospholipases A (PLA s) are found in almost every venomous snake family. In snakebites, some PLA s can quickly cause local myonecrosis, which may lead to permanent sequelae if antivenom is administered belatedly. They hydrolyse phospholipids in membranes through a catalytic calcium ions-dependent m...

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Veröffentlicht in:	International journal of biological macromolecules 2021-11, Vol.191, p.255
Hauptverfasser:	Borges, Rafael J, Salvador, Guilherme H M, Campanelli, Henrique B, Pimenta, Daniel C, de Oliveira Neto, Mario, Usón, Isabel, Fontes, Marcos R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Calcium - metabolism Crotalid Venoms - chemistry Crotalid Venoms - metabolism Group II Phospholipases A2 - chemistry Group II Phospholipases A2 - metabolism Molecular Dynamics Simulation Protein Binding Protein Multimerization
Online-Zugang:	Volltext
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