Liposome interaction with macrophages and foam cells for atherosclerosis treatment: effects of size, surface charge and lipid composition

Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease of surface modifications that allow them to have prolonged circulation half-life and specifically target atherosclerotic sites to increase uptake efficiency. However, the effects of their size, charg...

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Veröffentlicht in:	Nanotechnology 2021-12, Vol.32 (50), p.505105
Hauptverfasser:	Tang, Jinkai, Rakshit, Moumita, Chua, Huei Min, Darwitan, Anastasia, Nguyen, Luong T H, Muktabar, Aristo, Venkatraman, Subbu, Ng, Kee Woei
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - analogs & derivatives 1,2-Dipalmitoylphosphatidylcholine - chemistry Atherosclerosis - drug therapy Cell Line Cell Survival - drug effects cellular uptake Cholesterol - metabolism cholesterol efflux endocytosis Endocytosis - drug effects foam cell Foam Cells - cytology Foam Cells - metabolism Humans liposome Liposomes - chemistry Liposomes - pharmacology Liposomes - therapeutic use Macrophages - cytology Macrophages - metabolism Particle Size Phagocytosis - drug effects Surface Properties
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