Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of T H 1 and T H 2 cells
Polyphenols are a wide class of natural substances, pleiotropic molecules capable of modulating several processes, involved in the humoral and cellular immune response. The activation, differentiation of B cells, and production of antibodies to protein antigens by plasma cells depend on T helper (T...
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| Veröffentlicht in: | Current opinion in pharmacology 2021-10, Vol.60, p.315 |
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| container_title | Current opinion in pharmacology |
| container_volume | 60 |
| creator | Benvenuto, Monica Focaccetti, Chiara Ciuffa, Sara Fazi, Sara Bei, Arianna Miele, Martino Tony Albonici, Loredana Cifaldi, Loredana Masuelli, Laura Bei, Roberto |
| description | Polyphenols are a wide class of natural substances, pleiotropic molecules capable of modulating several processes, involved in the humoral and cellular immune response. The activation, differentiation of B cells, and production of antibodies to protein antigens by plasma cells depend on T helper (T
) CD4
cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of T
1/T
2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the T
1/T
2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of T
1 and T
2 cells. |
| doi_str_mv | 10.1016/j.coph.2021.08.005 |
| format | Article |
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) CD4
cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of T
1/T
2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the T
1/T
2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of T
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) CD4
cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of T
1/T
2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the T
1/T
2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of T
1 and T
2 cells.</description><subject>Autoimmune Diseases - immunology</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Infections - immunology</subject><subject>Neoplasms - immunology</subject><subject>Polyphenols - pharmacology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>1471-4973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFT0tOwzAUtJBQW6AXYIHeAajxJyF0jUBdsui-cp2XxpV_smOk3ITjklRlzWpG85OGkEfOKGf89eVMdYg9FUxwyt4oY_UNWfGq4Ztq28glucv5zBivpWwWZCmrWrBtJVbk5yvYMfbog82gug71AEOP0BcXkrKQMMfgM4LxoJXXmJ4nOsdMKFPDt6CsxXQyGlqTUWW8qmUIxrnizTDCcQQX2mLVYPzpsq-mge_ZCh3sYQf8UpqZAI3W5gdy2ymbcX3Fe_L0-bF_321iOTpsDzEZp9J4-Lsi_w38AjuPXAw</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Benvenuto, Monica</creator><creator>Focaccetti, Chiara</creator><creator>Ciuffa, Sara</creator><creator>Fazi, Sara</creator><creator>Bei, Arianna</creator><creator>Miele, Martino Tony</creator><creator>Albonici, Loredana</creator><creator>Cifaldi, Loredana</creator><creator>Masuelli, Laura</creator><creator>Bei, Roberto</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202110</creationdate><title>Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of T H 1 and T H 2 cells</title><author>Benvenuto, Monica ; Focaccetti, Chiara ; Ciuffa, Sara ; Fazi, Sara ; Bei, Arianna ; Miele, Martino Tony ; Albonici, Loredana ; Cifaldi, Loredana ; Masuelli, Laura ; Bei, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_345209423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autoimmune Diseases - immunology</topic><topic>Cytokines</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Infections - immunology</topic><topic>Neoplasms - immunology</topic><topic>Polyphenols - pharmacology</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benvenuto, Monica</creatorcontrib><creatorcontrib>Focaccetti, Chiara</creatorcontrib><creatorcontrib>Ciuffa, Sara</creatorcontrib><creatorcontrib>Fazi, Sara</creatorcontrib><creatorcontrib>Bei, Arianna</creatorcontrib><creatorcontrib>Miele, Martino Tony</creatorcontrib><creatorcontrib>Albonici, Loredana</creatorcontrib><creatorcontrib>Cifaldi, Loredana</creatorcontrib><creatorcontrib>Masuelli, Laura</creatorcontrib><creatorcontrib>Bei, Roberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Current opinion in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benvenuto, Monica</au><au>Focaccetti, Chiara</au><au>Ciuffa, Sara</au><au>Fazi, Sara</au><au>Bei, Arianna</au><au>Miele, Martino Tony</au><au>Albonici, Loredana</au><au>Cifaldi, Loredana</au><au>Masuelli, Laura</au><au>Bei, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of T H 1 and T H 2 cells</atitle><jtitle>Current opinion in pharmacology</jtitle><addtitle>Curr Opin Pharmacol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>60</volume><spage>315</spage><pages>315-</pages><eissn>1471-4973</eissn><abstract>Polyphenols are a wide class of natural substances, pleiotropic molecules capable of modulating several processes, involved in the humoral and cellular immune response. The activation, differentiation of B cells, and production of antibodies to protein antigens by plasma cells depend on T helper (T
) CD4
cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of T
1/T
2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the T
1/T
2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of T
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| fulltext | fulltext |
| identifier | EISSN: 1471-4973 |
| ispartof | Current opinion in pharmacology, 2021-10, Vol.60, p.315 |
| issn | 1471-4973 |
| language | eng |
| recordid | cdi_pubmed_primary_34520942 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Autoimmune Diseases - immunology Cytokines Humans Hypersensitivity - immunology Infections - immunology Neoplasms - immunology Polyphenols - pharmacology Th1 Cells - immunology Th2 Cells - immunology |
| title | Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of T H 1 and T H 2 cells |
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