A triple combination strategy of UHPLC-MS n , hypolipidemic activity and transcriptome sequencing to unveil the hypolipidemic mechanism of Nelumbo nucifera alkaloids

Nelumbo nucifera (N. nucifera), a kind of edible Chinese herbal, has been studied in treating hyperlipidemia. However, the hypolipidemic mechanism of N. nucifera remains unknown. Aims of this review: We aimed to screen the effective constituent of N. nucifera alkaloids and elucidated the potential m...

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Veröffentlicht in:	Journal of ethnopharmacology 2022-01, Vol.282, p.114608
Hauptverfasser:	Yang, Jiaying, Zhang, Yu, Jiang, Lijuan, Li, Caixia, Sun, Zhenxiao, Zhang, Yan, Lin, Tianfeng, Jiang, Yanyan, Liu, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Angiopoietin-Like Protein 4 - metabolism Aporphines - pharmacology Chromatography, High Pressure Liquid - methods Gene Expression Regulation - drug effects Hep G2 Cells Humans Hyperlipidemias - drug therapy Hyperlipidemias - metabolism Hypolipidemic Agents - pharmacology Nelumbo Peroxisome Proliferator-Activated Receptors - metabolism Receptors, LDL - metabolism Sequence Analysis, RNA - methods Signal Transduction - drug effects
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