Hepatokine Pregnancy Zone Protein Governs the Diet‐Induced Thermogenesis Through Activating Brown Adipose Tissue

Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter‐organ systems play a key role in IF remains unclear. Here, a novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant...

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Veröffentlicht in:	Advanced science 2021-11, Vol.8 (21), p.e2101991-n/a
Hauptverfasser:	Lin, Jun, Jiang, Xiaoxiao, Dong, Meng, Liu, Xiaomeng, Shen, Qiwei, Huang, Yuanyuan, Zhang, Hanlin, Ye, Rongcai, Zhou, Huiqiao, Yan, Chunlong, Yuan, Shouli, Wu, Xiangnan, Chen, Li, Wang, Yanfang, He, Min, Tao, Yi, Zhang, Zhaoyun, Jin, Wanzhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - metabolism Adult Animals Body fat Body mass index brown adipose tissue Cytochrome Diet, High-Fat Endoplasmic Reticulum Chaperone BiP - antagonists & inhibitors Endoplasmic Reticulum Chaperone BiP - genetics Endoplasmic Reticulum Chaperone BiP - metabolism Energy Female Food Gene expression Glucose Tolerance Test hepatokine Humans intermittent fasting Liver Male Metabolic disorders Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Obesity Obesity - metabolism Obesity - pathology Pregnancy Proteins - blood Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Proteins RNA Interference RNA, Small Interfering - metabolism Signal Transduction Statistical analysis Thermogenesis Thermogenesis - physiology Uncoupling Protein 1 - deficiency Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism Weight control
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