Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease

In the present study, mitral valve tissues from three mitral stenosis patients with RHD by valve replacement and two healthy donors were harvested and conducted DNA methylation signature on PRKCA by MeDIP-qPCR. The presence of hypomethylated CpG islands at promoter and 5ʹ terminal of PRKCA was obser...

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Veröffentlicht in:	Bioengineered 2021-01, Vol.12 (1), p.5904-5915
Hauptverfasser:	Xie, Zan, Wang, Qianli, Hu, Shaojuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 - metabolism dna methylation DNA Methylation - genetics dnmt1 Female Humans Male Middle Aged Mitral Valve - metabolism prkca-as1 Promoter Regions, Genetic - genetics protein kinase c alpha Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Research Paper Rheumatic heart disease Rheumatic Heart Disease - genetics Rheumatic Heart Disease - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism
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