Anti-tumour necrosis factor α antibodies and circulating lymphocyte phenotypes in inflammatory bowel disease

•CD70+ receptor is a marker of T cell activation during inflammatory bowel disease.•CD70+ T cells was significantly reduced by treatment with anti-TNFα antibodies.•CD3+ T cells were increased in anti-TNFα treated compared to untreated patients.•Relation between the drug behaviour and the lymphocytes...

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Veröffentlicht in:	International immunopharmacology 2021-11, Vol.100, p.108081-108081, Article 108081
Hauptverfasser:	Defendenti, Caterina, Tarkowski, Maciej, Borille, Simona, Cassinotti, Andrea, Massari, Alessandro, Birindelli, Sarah, Riva, Agostino, Ardizzone, Sandro, Panteghini, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab - pharmacology Adalimumab - therapeutic use Adult Aged Antibodies Biological drugs Biological effects CD19 antigen CD27 antigen CD27 ligand CD27 Ligand - analysis CD27 Ligand - metabolism CD3 antigen CD3 Complex - analysis CD3 Complex - metabolism CD45 antigen CD70 antigen Cell activation Female Flow cytometry Humans Immunological memory Immunology Immunophenotyping Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Infliximab Infliximab - pharmacology Infliximab - therapeutic use Intestine Life Sciences & Biomedicine Lymphocyte Activation - drug effects Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocytes Lymphocytes B Lymphocytes T Male Memory cells Middle Aged Monitoring Monoclonal antibodies Neutralization Parameters Patients Peripheral blood Pharmacology & Pharmacy Phenotypes Science & Technology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Telemedicine TNF inhibitors Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Tumors Tumour necrosis factor alpha
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