p16 INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells

T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular senescence features both and ....

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Veröffentlicht in:	Frontiers in immunology 2021, Vol.12, p.698565
Hauptverfasser:	Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J, Mallette, Frédérick A, Delisle, Jean-Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology Cellular Senescence - immunology Cyclin-Dependent Kinase Inhibitor p16 - immunology Humans Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Programmed Cell Death 1 Receptor - immunology
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