Structural insights into GIRK2 channel modulation by cholesterol and PIP 2

G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer's deme...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-08, Vol.36 (8), p.109619
Hauptverfasser:	Mathiharan, Yamuna Kalyani, Glaaser, Ian W, Zhao, Yulin, Robertson, Michael J, Skiniotis, Georgios, Slesinger, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol - metabolism Cryoelectron Microscopy - methods G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism GTP-Binding Proteins - metabolism Ion Channel Gating - physiology Mice Phosphatidylinositol 4,5-Diphosphate - metabolism Protein Binding Saccharomycetales
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